Invention Grant
US07169925B2 Indole derivatives as interleukin-4 gene expression inhibitors
失效
吲哚衍生物作为白细胞介素-4基因表达抑制剂
- Patent Title: Indole derivatives as interleukin-4 gene expression inhibitors
- Patent Title (中): 吲哚衍生物作为白细胞介素-4基因表达抑制剂
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Application No.: US10421511Application Date: 2003-04-23
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Publication No.: US07169925B2Publication Date: 2007-01-30
- Inventor: Gregory H. Merriman , Philip M. Weintraub , Jeffrey S. Sabol , Ramalinga M. Dharanipragada , Nicholas J. Hrib , John G. Jurcak , Alexandre Gross , Brian Whiteley , Kwon Yon Musick , Joseph T. Klein
- Applicant: Gregory H. Merriman , Philip M. Weintraub , Jeffrey S. Sabol , Ramalinga M. Dharanipragada , Nicholas J. Hrib , John G. Jurcak , Alexandre Gross , Brian Whiteley , Kwon Yon Musick , Joseph T. Klein
- Applicant Address: US NJ Bridgewater
- Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee Address: US NJ Bridgewater
- Agent Balaram Gupta
- Priority: GB0217920.8 20020802
- Main IPC: C07D403/12
- IPC: C07D403/12 ; C07D401/00
Abstract:
This invention discloses and claims a new class of indole derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.
Public/Granted literature
- US20040010029A1 Indole derivatives as interleukin -4 gene expression inhibitors Public/Granted day:2004-01-15
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