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    3-<4-substituted-4-piperazinyl)buty]-4-thiazolidinone and related compounds
    9.
    发明授权
    3-<4-substituted-4-piperazinyl)buty]-4-thiazolidinone and related compounds 失效
    3- [4-取代-4-哌嗪基]丁基] -4-噻唑烷酮及相关化合物

    公开(公告)号：US5371087A

    公开(公告)日：1994-12-06

    申请号：US85273

    申请日：1993-06-29

    申请人： Nicholas J. Hrib ,  John G. Jurcak

    发明人： Nicholas J. Hrib ,  John G. Jurcak

    IPC分类号： A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  A61P25/04 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D277/14 ,  C07D277/60 ,  C07D277/82 ,  C07D417/12 ,  C07D417/14 ,  C07D513/10 ,  A61K31/50 ,  C07D401/00 ,  C07D403/00

    CPC分类号： C07D277/60 ,  C07D277/14 ,  C07D277/82 ,  C07D417/12 ,  C07D417/14

    摘要： There are disclosed compounds of the formula, ##STR1## where n is 0, 1 or 2; A is ##STR2## where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; Y in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino cyano, trifluoromethyl or methylthio; m is 1 or 2; k is 1 or 2; R.sub.1 and R.sub.2 are independently hydrogen, loweralkyl, ##STR3## or aryl except that when R.sub.1 is ##STR4## or aryl, R.sub.2 is hydrogen, or alternatively R.sub.1 +R.sub.2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, indan or piperidine ring; R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl, or alternatively R.sub.3 +R.sub.4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl signifying an unsubstituted phenyl group or a phenyl group substituted with 1, 2 or 3 substituents each of which being independently loweralkyl, loweralkoxy, hydroxy, halogen, loweralkylthio, cyano, amino or trifluoromethyl, which are useful as antipsychotic, analgesic, anticonvulsant and anxiolytic agents.

    摘要翻译： 公开了下式的化合物，其中n为0,1或2; 其中每次出现的X独立为氢，卤素，低级烷基，羟基，硝基，低级烷氧基，氨基，氰基，三氟甲基或甲硫基; Y在每次出现时独立地是氢，卤素，低级烷基，羟基，硝基，低级烷氧基，氨基氰基，三氟甲基或甲硫基; m为1或2; k为1或2; R1和R2独立地是氢，低级烷基，低级或芳基，除了当R 1是芳基或芳基时，R 2是氢，或者R 1 + R 2与它们所连接的碳原子一起形成环戊烷，环己烷 ，环庚烷，吡喃，噻喃，茚满或哌啶环; R3和R4独立地是氢或低级烷基，或者R3 + R4与它们所连接的碳原子一起形成环戊烷，环己烷，环庚烷，吡喃，噻喃，吡咯烷或哌啶环，术语表示未取代的苯基的芳基 或被1,2或3个取代基取代的苯基，各自独立地为低级烷基，低级烷氧基，羟基，卤素，低级烷硫基，氰基，氨基或三氟甲基，其可用作抗精神病药，镇痛药，抗惊厥药和抗焦虑剂。