发明授权
- 专利标题： Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
- 专利标题（中）： 通过核苷位置修饰调节寡核苷酸CpG介导的免疫刺激
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申请号： US10365834申请日： 2003-02-13
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公开(公告)号： US07176296B2公开(公告)日： 2007-02-13
- 发明人: Sudhir Agrawal , Ekambar R. Kandimalla
- 申请人： Sudhir Agrawal , Ekambar R. Kandimalla
- 申请人地址： US MA Cambridge
- 专利权人： Idera Pharmaceuticals, Inc.
- 当前专利权人： Idera Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Keown & Associates
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/00 ; C07H19/00
摘要：
The invention provides compounds having increased or reduced immunostimulatory effect, said compounds comprising a CpG dinucleotide and an immunomodulatory moiety wherein the increased or reduced immunomodulatory effect is relative to a similar compound lacking the immunomodulatorv moiety.
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