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11 条记录 (耗时 0.015 秒)

    Micronized vitamin C formulation
    1.
    发明授权
    Micronized vitamin C formulation 有权
    微粉维生素C配方

    公开(公告)号：US07101563B1

    公开(公告)日：2006-09-05

    申请号：US09518554

    申请日：2000-03-03

    申请人： Jacob Vromen

    发明人： Jacob Vromen

    IPC分类号： A61K6/00 ,  A61K9/14

    CPC分类号： A61K9/0014

    摘要： Stable vitamin C (L-ascorbic acid) compositions for topical application, comprising micronized L-ascorbic acid in a substantially non-aqueous carrier having a pH greater than that of skin, and preferably not lower than approximately 5.5 and not greater than approximately 7.5, are described. The composition may further comprise papain as an enzymatic exfoliant in addition to humectants, emollients, viscosity-increasing agents, surfactants, and preservatives. Methods of preparing the micronized L-ascorbic acid for use in the described formulations, by a “wet” micronization process, are also described. The compositions are useful as UV protectants, promoters of collagen synthesis and in the removal and/or treatment of wrinkles.

    摘要翻译： 用于局部施用的稳定的维生素C（L-抗坏血酸）组合物，其包含在基本上非水性载体中的微粉化的L-抗坏血酸，其pH值大于皮肤，并且优选不低于约5.5并且不大于约7.5， 被描述。 除了保湿剂，软化剂，​​增粘剂，表面活性剂和防腐剂之外，组合物还可以包含作为酶促去角质剂的木瓜蛋白酶。 还描述了通过“湿”微粉化方法制备用于所述制剂的微粉化L-抗坏血酸的方法。 该组合物可用作UV保护剂，胶原合成促进剂和去除和/或治疗皱纹。

    MDM2-specific antisense oligonucleotides
    2.
    发明授权
    MDM2-specific antisense oligonucleotides 失效
    MDM2特异性反义寡核苷酸

    公开(公告)号：US06946447B2

    公开(公告)日：2005-09-20

    申请号：US09541848

    申请日：2000-04-03

    申请人： Jiandong Chen ,  Sudhir Agrawal ,  Ruiwen Zhang

    发明人： Jiandong Chen ,  Sudhir Agrawal ,  Ruiwen Zhang

    IPC分类号： A61K38/00 ,  C12N15/113 ,  A61K41/00 ,  C12Q1/68

    CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N15/1135 ,  C12N2310/315 ,  C12N2310/345 ,  C12N2310/346

    摘要： The invention provides methods to activate tumor suppressors. The invention further provides antisense oligonucleotides complementary to a portion of the MDM2-encoding RNA and methods for using such antisense oligonucleotides as analytical and diagnostic tools, as potentiators of transgenic animal studies and for gene therapy approaches, and as potential therapeutic agents. The invention also provides methods to augment and synergistically activate a tumor suppressor in conjunction with the use of a DNA-damage inducing agent. The invention further provides in vitro and in vivo models to evaluate the therapeutic effectiveness of a recently identified anti-human-MDM2 antisense oligonucleotide in the treatment of human colorectal cancers.

    摘要翻译： 本发明提供激活肿瘤抑制因子的方法。 本发明还提供了与一部分编码MDM2的RNA互补的反义寡核苷酸以及使用这样的反义寡核苷酸作为分析和诊断工具，作为转基因动物研究和基因治疗方法的增效剂以及作为潜在治疗剂的方法。 本发明还提供了与使用DNA损伤诱导剂一起增加和协同激活肿瘤抑制基因的方法。 本发明进一步提供体外和体内模型以评估最近鉴定的抗人MDM2反义寡核苷酸在治疗人结肠直肠癌中的治疗有效性。

    Acyl phosphonate inhibitors of β-lactamases
    3.
    发明授权
    Acyl phosphonate inhibitors of β-lactamases 失效
    β-内酰胺酶的酰基膦酸酯抑制剂

    公开(公告)号：US07205285B2

    公开(公告)日：2007-04-17

    申请号：US10628649

    申请日：2003-07-28

    申请人： Jeffrey M. Besterman ,  Jubrail Rahil ,  Rex Pratt

    发明人： Jeffrey M. Besterman ,  Jubrail Rahil ,  Rex Pratt

    IPC分类号： A61K31/66 ,  C07F9/02

    CPC分类号： C07F9/65744 ,  C07F9/096 ,  C07F9/098 ,  C07F9/4093 ,  C07F9/657181 ,  C07F9/65742

    摘要： The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not possess a β-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as β-lactamase inhibitors and as antibiotics.

    摘要翻译： 本发明提供了新型β-内酰胺酶抑制剂，其在结构上与目前可获得的天然产物和半合成β-内酰胺酶抑制剂无关，并且不具有β-内酰胺药效团。 这些新的抑制剂是完全合成的，可以方便地访问各种结构相关的类似物。 这些新抑制剂的某些实施方案也结合细菌DD-肽酶，因此潜在地作为β-内酰胺酶抑制剂和抗生素起作用。

    Method for detecting microorganisms and detection kit
    7.
    发明授权
    Method for detecting microorganisms and detection kit 失效

    公开(公告)号：US06984500B2

    公开(公告)日：2006-01-10

    申请号：US10215670

    申请日：2002-08-09

    申请人： Tomota Nakano ,  Makoto Kurihara

    发明人： Tomota Nakano ,  Makoto Kurihara

    IPC分类号： C12Q1/04 ,  C12Q1/18 ,  C12N5/00 ,  G01N33/53

    CPC分类号： C12Q1/18 ,  C12Q1/04 ,  Y10S435/975

    摘要： A method for detecting a microorganism by coloration is provided that includes adding and reacting, in a liquid culture medium, an alkaline sensitizing solution and a coloring reagent containing a redox dye, the liquid culture medium having been inoculated with a test sample, thereby detecting the microorganism by coloration in the reaction. There is also provided a method for testing drug susceptibility of a microorganism using above-mentioned method. Furthermore, kits used in these methods are provided. The invention is useful to assess readily and objectively the growth of microorganism when carrying out e.g. a detection of microorganism in foods and a test such as a drug susceptibility test.

    Replication protein a binding transcriptional factor (RBT1) and uses thereof
    10.
    发明授权
    Replication protein a binding transcriptional factor (RBT1) and uses thereof 失效
    复制蛋白结合转录因子（RBT1）及其用途

    公开(公告)号：US07094891B1

    公开(公告)日：2006-08-22

    申请号：US10069386

    申请日：2000-08-17

    申请人： Moulay A. Alaoui-Jamali ,  John Myung-Jae Cho

    发明人： Moulay A. Alaoui-Jamali ,  John Myung-Jae Cho

    IPC分类号： C07H21/00 ,  C07K14/00 ,  C12N15/83 ,  C12N15/86

    CPC分类号： C07K14/4705

    摘要： The present invention relates to replication protein A (RPA) transcriptional factors. There is provided a nucleotide sequence encoding a replication protein A transcriptional activator 1 (RTB1) and a protein encoded by such a nucleotide sequence. RBT1 has a high activity and is highly transactivated in cancer cells. The sequence may be used to treat neoplastic disorders and in gene therapy.

    摘要翻译： 本发明涉及复制蛋白A（RPA）转录因子。 提供了编码复制蛋白A转录激活物1（RTB1）的核苷酸序列和由这种核苷酸序列编码的蛋白质。 RBT1具有高活性，在癌细胞中高度反式激活。 该序列可用于治疗肿瘤疾病和基因治疗。