Invention Grant
- Patent Title: Process for the synthesis of oligomeric compounds
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Application No.: US10940360Application Date: 2004-09-14
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Publication No.: US07199236B2Publication Date: 2007-04-03
- Inventor: Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
- Applicant: Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Woodcock Washburn LLP
- Main IPC: C07H21/00
- IPC: C07H21/00
Abstract:
Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
Public/Granted literature
- US20050137391A1 Process for the synthesis of oligomeric compounds Public/Granted day:2005-06-23
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