- 专利标题： Process for the synthesis of oligomeric compounds
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申请号： US10940360申请日： 2004-09-14
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公开(公告)号： US07199236B2公开(公告)日： 2007-04-03
- 发明人: Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
- 申请人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Woodcock Washburn LLP
- 主分类号： C07H21/00
- IPC分类号： C07H21/00
摘要：
Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
公开/授权文献
- US20050137391A1 Process for the synthesis of oligomeric compounds 公开/授权日：2005-06-23
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