发明授权
US07216041B1 Methods of using the structure coordinates of molecules comprising an IMPDH-like binding pocket
失效
使用包含IMPDH样结合口袋的分子的结构坐标的方法
- 专利标题： Methods of using the structure coordinates of molecules comprising an IMPDH-like binding pocket
- 专利标题（中）： 使用包含IMPDH样结合口袋的分子的结构坐标的方法
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申请号： US09678016申请日： 2000-10-02
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公开(公告)号： US07216041B1公开(公告)日： 2007-05-08
- 发明人: Keith P. Wilson , Michael D. Sintchak , Mark Andrew Fleming , David M. Armistead
- 申请人： Keith P. Wilson , Michael D. Sintchak , Mark Andrew Fleming , David M. Armistead
- 申请人地址： US MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Cambridge
- 代理机构： Fish & Neave IP Group Ropes & Gray LLP
- 代理商 James F. Haley
- 主分类号： G06F19/00
- IPC分类号： G06F19/00
摘要：
The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.
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