公开(公告)号：US07306903B1

公开(公告)日：2007-12-11

申请号：US09613177

申请日：2000-07-10

申请人： Kuber T. Sampath ,  Shun-ichi Harada ,  Gideon A. Rodan

发明人： Kuber T. Sampath ,  Shun-ichi Harada ,  Gideon A. Rodan

IPC分类号： C12Q1/68

CPC分类号： C07K14/4705 ,  A61K38/00 ,  C07K14/51

摘要： Disclosed herein are methods and compositions for identifying morphogen analogs. The preferred methods and compositions relate to the discovery that morphogen upregulation of the mouse type X collagen promoter activity is mediated by a MEF-2 like sequence and requires an adjacent AP-1 sequence. Certain methods rest on the use of test cells comprising DNA defining a morphogen-responsive transcription activating element operatively associated with a reporter gene. Other methods rest on the use of DNAs for measuring morphogen-inducible DNA-binding. In certain preferred embodiments, the methods and DNAs involve an osteogenic protein 1 (OP-1) responsive transcription activating element. Substances that mediate interaction with and/or activate the OP-1 responsive transcription activating element are considered herein likely to be useful for reproducing in vivo effects of morphogens such as OP-1.

摘要翻译： 本文公开了用于鉴定形态发生类似物的方法和组合物。 优选的方法和组合物涉及小鼠X型胶原启动子活性的形态发生上调由MEF-2样序列介导并需要相邻的AP-1序列的发现。 某些方法依赖于使用测试细胞，其包括定义与报告基因可操作地相关的形态发生反应性转录激活元件的DNA。 其他方法依赖于使用DNA来测量形态发生诱导型DNA结合。 在某些优选的实施方案中，所述方法和DNA涉及成骨蛋白1（OP-1）响应转录激活元件。 介导与OP-1反应性转录激活元件的相互作用和/或激活的物质在本文中被认为可能用于再现诸如OP-1的形态发生体的作用。

公开(公告)号：US07279175B2

公开(公告)日：2007-10-09

申请号：US10245840

申请日：2002-09-17

申请人： Jianbing Chen ,  Paul Ashton

发明人： Jianbing Chen ,  Paul Ashton

IPC分类号： A61F2/02 ,  A61F2/06

CPC分类号： A61K9/0024 ,  A61K9/7007 ,  A61K31/513 ,  A61K47/32 ,  A61K47/34 ,  A61L17/005 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/222 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/606

摘要： An intraluminal medical device comprises a stent having a coating applied to at least part of an interior surface, an exterior surface, or both. The coating comprises a sustained release formulation of a combination of pharmaceutical compounds dispersed within a biologically tolerated polymer composition. The choice of the combination of pharmaceutical compounds are intended to reduce neointimal hyperplasia restenosis.

摘要翻译： 管腔内医疗装置包括具有施加到内表面，外表面或两者的至少一部分的涂层的支架。 该涂层包含分散在生物耐受的聚合物组合物中的药物化合物的组合的持续释放制剂。 药物化合物的组合的选择旨在减少新生内膜增生再狭窄。

公开(公告)号：USD551875S1

公开(公告)日：2007-10-02

申请号：US29256241

申请日：2006-03-17

申请人： Luca Ricci

设计人： Luca Ricci

公开(公告)号：US07271027B2

公开(公告)日：2007-09-18

申请号：US11182427

申请日：2005-07-14

申请人： Suan Jeung Boon ,  Yong Poo Chia ,  Siu Waf Low ,  Meow Koon Eng ,  Swee Kang Chua ,  Shuang Wu Huang ,  Yong Loo Neo ,  Wei Zhou

发明人： Suan Jeung Boon ,  Yong Poo Chia ,  Siu Waf Low ,  Meow Koon Eng ,  Swee Kang Chua ,  Shuang Wu Huang ,  Yong Loo Neo ,  Wei Zhou

IPC分类号： H01L21/44

CPC分类号： H01L25/50 ,  H01L23/3114 ,  H01L23/49805 ,  H01L24/05 ,  H01L24/24 ,  H01L25/105 ,  H01L2224/02371 ,  H01L2224/04105 ,  H01L2224/05624 ,  H01L2224/05647 ,  H01L2224/73267 ,  H01L2224/85399 ,  H01L2225/06551 ,  H01L2225/1035 ,  H01L2225/107 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01014 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/0105 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/05042 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/181 ,  H01L2924/18162 ,  H01L2924/30105 ,  H01L2224/45099 ,  H01L2924/00

摘要： Systems and methods for packaging integrated circuit chips in castellation wafer level packaging are provided. The active circuit areas of the chips are coupled to castellation blocks and, depending on the embodiment, input/output pads. The castellation blocks and input/output pads are encapsulated and held in place by an encapsulant. When the devices are being fabricated, the castellation blocks and input/output pads are sawed through. If necessary, the wafer portion on which the devices are fabricated may be thinned. The packages may be used as a leadless chip carrier package or may be stacked on top of one another. When stacked, the respective contacts of the packages are preferably coupled. Data may be written to, and received from, packaged chips when a chip is activated. Chips may be activated by applying the appropriate signal or signals to the appropriate contact or contacts.

公开(公告)号：US07269091B2

公开(公告)日：2007-09-11

申请号：US10971939

申请日：2004-10-22

申请人： Hirokazu Ueda

发明人： Hirokazu Ueda

IPC分类号： G11C8/00 ,  G11C5/06 ,  G11C7/00

CPC分类号： G11C8/08 ,  G11C11/4085 ,  G11C11/413

摘要： Word line driver circuitry for selectively charging and discharging one or more word lines is provided. The driver circuitry uses a dual transistor topology, where a first transistor is driven by a signal, DOUT, and a second transistor is driven by a time-delayed complement of the DOUT, DOUT_BAR. The time delay prevents DOUT_BAR from changing its state immediately after DOUT changes state. As result, both the first and second transistors are turned ON at the same time for a predetermined of time. It is during this time that the voltage on the word line is rapidly driven to a LOW voltage. When the second transistor turns OFF, high impedance circuitry limits the flow of leakage current. This minimizes leakage current when the word line is OFF and when short circuit conditions are present between two or more word lines or between a word line and a bit line.

摘要翻译： 提供用于选择性地对一个或多个字线进行充电和放电的字线驱动器电路。 驱动器电路使用双晶体管拓扑，其中第一晶体管由信号DOUT驱动，并且第二晶体管由DOUT DOUT_BAR的时间延迟的补码驱动。 时间延迟可防止DOUT_BAR在DOUT更改状态后立即更改其状态。 结果，第一和第二晶体管同时接通预定的时间。 在这段时间内，字线上的电压被快速驱动到低电压。 当第二个晶体管关断时，高阻抗电路会限制漏电流。 当字线为OFF并且在两条或多条字线之间或字线与位线之间存在短路状况时，这将使漏电流最小化。

公开(公告)号：US07264968B2

公开(公告)日：2007-09-04

申请号：US10721692

申请日：2003-11-25

申请人： Douglas A. Melton ,  Ali Hemmati-Brivanlou

发明人： Douglas A. Melton ,  Ali Hemmati-Brivanlou

IPC分类号： C12N5/00

CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K38/22 ,  A61K38/57 ,  C07K14/46 ,  C07K14/71 ,  A61K2300/00

摘要： The present invention makes available a method for inducing neuronal differentiation and preventing the death or degeneration of neuronal cells both in vitro and in vivo. The subject method stems from the unexpected finding that, contrary to traditional understanding of neural induction, the default fate of ectodermal tissue is neuronal rather than mesodermal and/or epidermal. In particular, it has been discovered that preventing or antagonizing a signaling pathway in a cell for a growth factor of the TGF-β family can result in neuronal differentiation of that cell.

摘要翻译： 本发明提供一种用于诱导神经元分化并在体外和体内预防神经元细胞的死亡或退化的方法。 主题方法源于意想不到的发现，与传统的神经诱导理解相反，外胚层组织的默认命运是神经元而不是中胚层和/或表皮。 特别地，已经发现，预防或拮抗TGF-β家族生长因子的细胞中的信号传导途径可导致该细胞的神经元分化。

公开(公告)号：US07257780B2

公开(公告)日：2007-08-14

申请号：US09924274

申请日：2001-08-07

申请人： Paul Metzgen

发明人： Paul Metzgen

IPC分类号： G06F17/50

CPC分类号： G06F17/505 ,  G06F17/5045 ,  G06F17/5054

摘要： A hardware-to-software compiler is provided that runs an optimization on a circuit implemented in programmable logic. The optimization allows portions of the program implemented by the circuit to be executed via software. A communication interface between the hardware and software is provided that allows for efficient data flow. A communication channel is provided that can be effected as bidirectional using a unidirectional transport medium (e.g., PCI bus). Communication between devices is done through pop interface buffers and push interface buffers on either side of the communication channel.

摘要翻译： 提供了一种硬件到软件的编译器，可以在可编程逻辑中实现的电路上进行优化。 优化允许由电路实现的程序的部分通过软件执行。 提供硬件和软件之间的通信接口，允许有效的数据流。 提供可以使用单向传输介质（例如，PCI总线）作为双向实现的通信信道。 通过弹出界面缓冲区和通信通道两侧的推送接口缓冲区来实现设备之间的通信。

公开(公告)号：USD547968S1

公开(公告)日：2007-08-07

申请号：US29233757

申请日：2005-07-08

申请人： Luca Ricci

设计人： Luca Ricci

公开(公告)号：US07252681B2

公开(公告)日：2007-08-07

申请号：US10368085

申请日：2003-02-13

申请人： Todd A Berg ,  Alex A Peterson ,  Matthew W Weston

发明人： Todd A Berg ,  Alex A Peterson ,  Matthew W Weston

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2220/0075

摘要： A replacement heart valve structure including a structure of tissue which is an intact, mammalian heart valve that has been harvested and treated to preserve it. A conventional fabric sleeve is typically disposed concentrically around the outside of the tissue structure. A support structure is included to facilitate implanting the heart valve by somewhat increasing the stability of the heart valve structure, but without unduly rigidifying it. An annular sewing cuff may be added adjacent the blood inflow end of the valve structure to facilitate making the annular suture line that is required at that end.

摘要翻译： 替代心脏瓣膜结构，其包括组织的结构，其是已经被收获并被处理以保存的完整的哺乳动物心脏瓣膜。 传统的织物套筒通常围绕组织结构的外部同心地设置。 包括支撑结构以便于通过稍微增加心脏瓣膜结构的稳定性而不会使其过度硬化来植入心脏瓣膜。 可以在阀结构的血液流入端附近添加环形缝合箍，以便于制造在该端所需的环形缝合线。

公开(公告)号：USD546091S1

公开(公告)日：2007-07-10

申请号：US29233765

申请日：2005-07-08

申请人： Luca Ricci

设计人： Luca Ricci