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    Methods of using the structure coordinates of molecules comprising an IMPDH-like binding pocket
    1.
    发明授权
    Methods of using the structure coordinates of molecules comprising an IMPDH-like binding pocket 失效
    使用包含IMPDH样结合口袋的分子的结构坐标的方法

    公开(公告)号：US07216041B1

    公开(公告)日：2007-05-08

    申请号：US09678016

    申请日：2000-10-02

    申请人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    发明人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    IPC分类号： G06F19/00

    CPC分类号： C12Q1/32 ,  C07K2299/00 ,  C12N9/0006 ,  C12Y101/01205 ,  G06F19/706

    摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.

    摘要翻译： 本发明涉及用包含IMPDH的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。 这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。 本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。 本发明还涉及作为IMPDH抑制剂的化合物和药物组合物。

    Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
    2.
    发明授权
    Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them 失效
    包含IMPDH样结合袋的分子和能够图形显示它们的编码数据存储介质

    公开(公告)号：US06128582A

    公开(公告)日：2000-10-03

    申请号：US640164

    申请日：1996-04-30

    申请人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    发明人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    IPC分类号： A61K31/00 ,  A61K31/365 ,  A61K45/00 ,  A61P43/00 ,  C07K1/00 ,  C07K1/14 ,  C12N9/04 ,  C12Q1/32 ,  G06F17/30 ,  G06F17/50 ,  G06F19/00

    CPC分类号： C12Q1/32 ,  C12N9/0006 ,  C12Y101/01205 ,  G06F19/706 ,  C07K2299/00

    摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.

    摘要翻译： 本发明涉及用包含IMPDH的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。 这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。 本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。 本发明还涉及作为IMPDH抑制剂的化合物和药物组合物。

    Crystals of inosine monophosphate dehydrogenase/oxidized inosine monophosphate thiomidate intermediate/mycophenolic acid (IIMPDH/XMP*/MPA)
    4.
    发明授权
    Crystals of inosine monophosphate dehydrogenase/oxidized inosine monophosphate thiomidate intermediate/mycophenolic acid (IIMPDH/XMP*/MPA) 失效
    肌苷单磷酸脱氢酶/氧化肌苷单磷酸硫酸酯中间体/霉酚酸（IIMPDH / XMP * / MPA）

    公开(公告)号：US07527952B2

    公开(公告)日：2009-05-05

    申请号：US11645289

    申请日：2006-12-21

    申请人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    发明人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    IPC分类号： C12P21/06 ,  C12N9/04

    CPC分类号： C12Q1/32 ,  C07K2299/00 ,  C12N9/0006 ,  C12Y101/01205 ,  G06F19/706

    摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.

    摘要翻译： 本发明涉及用包含IMPDH的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。 这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。 本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。 本发明还涉及作为IMPDH抑制剂的化合物和药物组合物。