Invention Grant
US07226758B1 Nucleic acids encoding glial cell line-derived neurotrophic factor (GDNF)
失效
编码胶质细胞系的神经营养因子（GDNF）的核酸
- Patent Title: Nucleic acids encoding glial cell line-derived neurotrophic factor (GDNF)
- Patent Title (中): 编码胶质细胞系的神经营养因子（GDNF）的核酸
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Application No.: US08182183Application Date: 1992-09-17
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Publication No.: US07226758B1Publication Date: 2007-06-05
- Inventor: Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
- Applicant: Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Robert L. Sharp; Ron K. Levy; Stuart Watt
- International Application: PCT/US92/07888 WO 19920917
- Main IPC: C12N15/18
- IPC: C12N15/18 ; C12N15/85 ; C12N15/63 ; C12N15/70
Abstract:
A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.
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