发明授权
- 专利标题： Protein C or activated protein C-like molecules
- 专利标题（中）： 蛋白C或活化蛋白C样分子
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申请号： US11004111申请日： 2004-12-03
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公开(公告)号： US07226999B2公开(公告)日： 2007-06-05
- 发明人: Kim Vilbour Andersen , Anders Hjelholt Pedersen , Per Ola Freskgaard
- 申请人： Kim Vilbour Andersen , Anders Hjelholt Pedersen , Per Ola Freskgaard
- 申请人地址： DK Hoersholm KY Grand Caymen
- 专利权人： Maxygen ApS,Maxygen Holdings Ltd.
- 当前专利权人： Maxygen ApS,Maxygen Holdings Ltd.
- 当前专利权人地址： DK Hoersholm KY Grand Caymen
- 代理商 Joanne R. Petithory; Norman J. Kruse
- 优先权： DKPA200001560 20001018; DKPA200100970 20010621
- 主分类号： A61K35/14
- IPC分类号： A61K35/14 ; A61K38/48 ; C07K14/00
摘要：
The present invention relates to novel conjugates between polypeptide variants of protein C and a non-polypeptide moiety, such as PEG or sugar moieties. In particular, the present invention provides novel protein C conjugates having an increased resistance to inactivation by e.g. human plasma and α1-antitrypsin. Consequently, such conjugates have an increased in vivo half-life. Preferred examples include protein C conjugates, wherein at least one additional in vivo N-glycosylation site has been introduced. The conjugates of the invention are useful for treating a variety of diseases, including septic shock.
公开/授权文献
- US20050095668A1 Protein C or activated protein C-like molecules 公开/授权日：2005-05-05
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