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公开(公告)号：US07226999B2
公开(公告)日：2007-06-05
申请号：US11004111
申请日：2004-12-03
CPC分类号： C12N9/6464 , C12Y304/21069
摘要： The present invention relates to novel conjugates between polypeptide variants of protein C and a non-polypeptide moiety, such as PEG or sugar moieties. In particular, the present invention provides novel protein C conjugates having an increased resistance to inactivation by e.g. human plasma and α1-antitrypsin. Consequently, such conjugates have an increased in vivo half-life. Preferred examples include protein C conjugates, wherein at least one additional in vivo N-glycosylation site has been introduced. The conjugates of the invention are useful for treating a variety of diseases, including septic shock.
摘要翻译： 本发明涉及蛋白质C的多肽变体与非多肽部分如PEG或糖部分之间的新型缀合物。 特别地，本发明提供了新的蛋白质C缀合物，其具有增强的抗失活能力。 人血浆和α1 - 抗胰蛋白酶。 因此，这种缀合物具有增加的体内半衰期。 优选的实例包括蛋白质C缀合物，其中已经引入至少一个额外的体内N-糖基化位点。 本发明的缀合物可用于治疗各种疾病，包括败血性休克。
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公开(公告)号：US06933367B2
公开(公告)日：2005-08-23
申请号：US09997623
申请日：2001-11-29
CPC分类号： C12N9/6464 , C12Y304/21069
摘要： The present invention relates to novel conjugates between polypeptide variants of protein C and a non-polypeptide moiety, such as PEG or sugar moieties. In particular, the present invention provides novel protein C conjugates having an increased resistance to inactivation by e.g. human plasma and α1-antitrypsin. Consequently, such conjugates have an increased in vivo half-life. Preferred examples include protein C conjugates, wherein at least one additional in vivo N-glycosylation site has been introduced. The conjugates of the invention are useful for treating a variety of diseases, including septic shock.
摘要翻译： 本发明涉及蛋白质C的多肽变体与非多肽部分如PEG或糖部分之间的新型缀合物。 特别地，本发明提供了新的蛋白质C缀合物，其具有增强的抗失活能力。 人血浆和α1 - 抗胰蛋白酶。 因此，这种缀合物具有增加的体内半衰期。 优选的实例包括蛋白质C缀合物，其中已经引入至少一个额外的体内N-糖基化位点。 本发明的缀合物可用于治疗各种疾病，包括败血性休克。
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