Invention Grant
- Patent Title: Method using crystal structure of estrogen receptor-β complex
- Patent Title (中): 使用雌激素受体-β复合物晶体结构的方法
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Application No.: US09903876Application Date: 2001-07-11
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Publication No.: US07235367B2Publication Date: 2007-06-26
- Inventor: William S. Somers , Zhang-Bao Xu , Tatos N. Akopian , Chu-Lai Hsiao , Rayomand Unwalla
- Applicant: William S. Somers , Zhang-Bao Xu , Tatos N. Akopian , Chu-Lai Hsiao , Rayomand Unwalla
- Applicant Address: US MA Cambridge
- Assignee: Genetics Institute, LLC.
- Current Assignee: Genetics Institute, LLC.
- Current Assignee Address: US MA Cambridge
- Agency: Fish & Richardson P.C.
- Main IPC: G01N23/20
- IPC: G01N23/20 ; G01N33/53
Abstract:
This invention is directed to the crystal structure of Estrogen Receptor-β (ER-β) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-β, which may be useful as novel chemotherapeutic agents.
Public/Granted literature
- US20020072587A1 Crystal structure of estrogen receptor-beta complex and uses thereof Public/Granted day:2002-06-13
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