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公开(公告)号：US20060074128A1
公开(公告)日：2006-04-06
申请号：US11247361
申请日：2005-10-11
Applicant: Christopher Miller , Michael Collini , David Kaufman , Robert Morris , Robert Singhaus , John Ullrich , Heather Harris , James Keith , Leo Albert , Rayomand Unwalla
Inventor： Christopher Miller , Michael Collini , David Kaufman , Robert Morris , Robert Singhaus , John Ullrich , Heather Harris , James Keith , Leo Albert , Rayomand Unwalla
IPC: A61K31/343 , C07D307/87
CPC classification number: C07D307/80 , C07D405/06 , C07D413/04
Abstract: This invention provides estrogen receptor modulators of formula 1, having the structure wherein R, R′, A, A′, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.
Abstract translation: 本发明提供式1的雌激素受体调节剂，其具有其中R，R'，A，A'，X，Y和Y如说明书中所定义的结构或其药学上可接受的盐。
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公开(公告)号：US20060030612A1
公开(公告)日：2006-02-09
申请号：US11194263
申请日：2005-08-01
Applicant: Robert Steffan , Edward Matelan , Stephen Bowen , John Ullrich , Jay Wrobel , Edouard Zamaratski , Lars Kruger , Annabel Hedemyr , Aiping Cheng , Tomas Hansson , Rayomand Unwalla , Christopher Miller , Patrik Rhonnstad
Inventor： Robert Steffan , Edward Matelan , Stephen Bowen , John Ullrich , Jay Wrobel , Edouard Zamaratski , Lars Kruger , Annabel Hedemyr , Aiping Cheng , Tomas Hansson , Rayomand Unwalla , Christopher Miller , Patrik Rhonnstad
IPC: C07D231/56 , A61K31/4162
CPC classification number: C07D403/04 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D491/10
Abstract: This invention provides compounds of Formula (I) or (Ia): that are useful in the treatment or inhibition of LXR mediated diseases.
Abstract translation: 本发明提供式（I）或（Ia）化合物：其可用于治疗或抑制LXR介导的疾病。
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公开(公告)号：US07235367B2
公开(公告)日：2007-06-26
申请号：US09903876
申请日：2001-07-11
Applicant: William S. Somers , Zhang-Bao Xu , Tatos N. Akopian , Chu-Lai Hsiao , Rayomand Unwalla
Inventor： William S. Somers , Zhang-Bao Xu , Tatos N. Akopian , Chu-Lai Hsiao , Rayomand Unwalla
CPC classification number: C07K14/70567 , C07K2299/00
Abstract: This invention is directed to the crystal structure of Estrogen Receptor-β (ER-β) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-β, which may be useful as novel chemotherapeutic agents.
Abstract translation: 本发明涉及与染料木黄酮复合的雌激素受体-β（ER-β）的晶体结构，以及在合理药物设计方法中使用该结构来鉴定可与ER-β的活性位点相互作用的药剂 作为新型化学治疗剂有用。
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Patent Agency Ranking
公开(公告)号：US20060252757A1
公开(公告)日：2006-11-09
申请号：US11365750
申请日：2006-03-01
Applicant: Baihua Hu , Jay Wrobel , Michael Collini , Rayomand Unwalla
Inventor： Baihua Hu , Jay Wrobel , Michael Collini , Rayomand Unwalla
IPC: A61K31/502 , C07D237/28 , A61K31/655
CPC classification number: C07D413/12 , C07D237/28 , C07D403/12 , C07D409/12
Abstract: This invention relates generally to cinnoline-based modulators of Liver X receptors (LXRs) and related methods.
Abstract translation: 本发明一般涉及基于噌啉的肝X受体调节剂（LXR）及相关方法。
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公开(公告)号：US20050131014A1
公开(公告)日：2005-06-16
申请号：US11010236
申请日：2004-12-10
Applicant: Michael Collini , Robert Singhaus , Baihua Hu , James Jetter , Robert Morris , David Kaufman , Christopher Miller , John Ullrich , Rayomand Unwalla , Jay Wrobel , Elaine Quinet , Ponnal Nambi , Ronald Bernotas , Merle Elloso
Inventor： Michael Collini , Robert Singhaus , Baihua Hu , James Jetter , Robert Morris , David Kaufman , Christopher Miller , John Ullrich , Rayomand Unwalla , Jay Wrobel , Elaine Quinet , Ponnal Nambi , Ronald Bernotas , Merle Elloso
IPC: A61K31/47 , A61K31/4709 , C07D215/14 , C07D215/54 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12 , C07D41/02
CPC classification number: C07D401/04 , C07D215/14 , C07D215/54 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12
Abstract: This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases.
Abstract translation: 本发明提供可用于治疗或抑制LXR介导的疾病的式I化合物。
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公开(公告)号：US20050038107A1
公开(公告)日：2005-02-17
申请号：US10828970
申请日：2004-04-21
Applicant: Christopher Miller , Michael Collini , David Kaufman , Robert Morris , Robert Singhaus , John Ullrich , Heather Harris , James Keith , Leo Albert , Rayomand Unwalla
Inventor： Christopher Miller , Michael Collini , David Kaufman , Robert Morris , Robert Singhaus , John Ullrich , Heather Harris , James Keith , Leo Albert , Rayomand Unwalla
IPC: A61P5/00 , C07D307/80 , C07D405/06 , C07D413/04 , A61K31/343 , C07D307/78
CPC classification number: C07D307/80 , C07D405/06 , C07D413/04
Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R, R′, A, A′, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.
Abstract translation: 本发明提供式I的雌激素受体调节剂，其具有其中R，R'，A，A'，X，Y和Y如说明书中所定义的结构或其药学上可接受的盐。
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7.发明申请公开(公告)号：US20080227960A1
公开(公告)日：2008-09-18
申请号：US11787175
申请日：2007-04-13
Applicant: William S. Somers , Zhang-Bao Xu , Tatos N. Akopian , Chu-Lai Hsiao , Rayomand Unwalla
Inventor： William S. Somers , Zhang-Bao Xu , Tatos N. Akopian , Chu-Lai Hsiao , Rayomand Unwalla
IPC: C07K14/575
CPC classification number: C07K14/70567 , C07K2299/00
Abstract: This invention is directed to the crystal structure of Estrogen Receptor-β (ER-β) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-β, which may be useful as novel chemotherapeutic agents.
Abstract translation: 本发明涉及与染料木黄酮复合的雌激素受体-β（ER-β）的晶体结构，以及在合理药物设计方法中使用该结构来鉴定可与ER-β的活性位点相互作用的药剂 作为新型化学治疗剂有用。
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公开(公告)号：US20060074081A1
公开(公告)日：2006-04-06
申请号：US11208303
申请日：2005-08-19
Applicant: Andrea Olland , James Wilhelm , Karl Malakian , Rayomand Unwalla
Inventor： Andrea Olland , James Wilhelm , Karl Malakian , Rayomand Unwalla
IPC: A61K31/538 , G06F19/00 , C07K14/72
CPC classification number: C07K14/721 , C07K2299/00
Abstract: This invention relates to progesterone receptor/ligand complexes, and related methods and software systems.
Abstract translation: 本发明涉及孕酮受体/配体复合物，以及相关方法和软件系统。
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