Invention Grant
US07235647B2 Intermediate and process for preparing of β- anomer enriched 21-deoxy,21,21-difluoro-D-ribofuranosyl nucleosides
有权
制备富含β-异头物的21-脱氧，21,21-二氟-D-呋喃核糖核苷的中间体和方法
- Patent Title: Intermediate and process for preparing of β- anomer enriched 21-deoxy,21,21-difluoro-D-ribofuranosyl nucleosides
- Patent Title (中): 制备富含β-异头物的21-脱氧，21,21-二氟-D-呋喃核糖核苷的中间体和方法
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Application No.: US11332830Application Date: 2006-01-13
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Publication No.: US07235647B2Publication Date: 2007-06-26
- Inventor: Golak Chandra Maikap , Deependra Bhatt , Bijan Kumar Panda
- Applicant: Golak Chandra Maikap , Deependra Bhatt , Bijan Kumar Panda
- Applicant Address: IN New Delhi
- Assignee: Dabur Pharma Limited
- Current Assignee: Dabur Pharma Limited
- Current Assignee Address: IN New Delhi
- Agency: Schwegman, Lundberg, Woessner and Kluth P.A.
- Priority: IN472/DEL/2005 20050304
- Main IPC: C07H5/04
- IPC: C07H5/04 ; C07H5/06 ; C07H19/00
Abstract:
The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of β-anomer enriched 21-deoxy-21,21-D-ribofuranosyl difluoronucleosides of formula (II), and physiologically acceptable slats thereof, in particular, the β-enriched anomer of gemcitabine hydrochloride of formula (IIb) in purity of >99% is provided through utilization of a novel trichloroacetimidate of formula (I).
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