公开(公告)号：US11597731B2

公开(公告)日：2023-03-07

申请号：US17378663

申请日：2021-07-17

Applicant: Akshay Kant Chaturvedi ,  Bijan Kumar Panda ,  Amit Kumar ,  Deepali Chaturvedi

Inventor： Akshay Kant Chaturvedi ,  Bijan Kumar Panda ,  Amit Kumar ,  Deepali Chaturvedi

IPC: C07D259/00 ,  C07D487/04 ,  C07C273/18

Abstract: The present invention provides a new process for preparation of imidazo-tetrazine class of chemical entity useful as anticancer agent. The present invention provides a commercially and economically viable process for preparation of Temozolomide of formula (VI). Present invention also relates to an intermediate compound of formula (III) and its preparation useful in the process for preparing Temozolomide.

公开(公告)号：US20240327374A1

公开(公告)日：2024-10-03

申请号：US18129074

申请日：2023-03-31

Applicant: Akshay Kant Chaturvedi ,  Mohammad Baqer ,  Bijan Kumar Panda ,  Satyaveer ,  Deepali Chaturvedi ,  Saroj Bala ,  Yogesh Tripathi

Inventor： Akshay Kant Chaturvedi ,  Mohammad Baqer ,  Bijan Kumar Panda ,  Satyaveer ,  Deepali Chaturvedi ,  Saroj Bala ,  Yogesh Tripathi

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07B2200/13

Abstract: The present invention provides to an improved process for the preparation of new and high purity crystalline Form SRA of 3-(4-amino-1-oxoisoindolin-2-yl) piperidine-2, 6-dione of formula (I)




The pure crystalline Form SRA of compound of formula (I) obtained by the process of present invention is having purity of greater than 99.9% (area % by HPLC).
Lenalidomide (I) pure crystalline Form SRA is useful in the treatment of cancer, inflammatory diseases, autoimmune diseases and Multiple myeloma.

公开(公告)号：US07235647B2

公开(公告)日：2007-06-26

申请号：US11332830

申请日：2006-01-13

Applicant: Golak Chandra Maikap ,  Deependra Bhatt ,  Bijan Kumar Panda

Inventor： Golak Chandra Maikap ,  Deependra Bhatt ,  Bijan Kumar Panda

IPC: C07H5/04 ,  C07H5/06 ,  C07H19/00

CPC classification number: C07H19/073 ,  C07H13/08

Abstract: The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of β-anomer enriched 21-deoxy-21,21-D-ribofuranosyl difluoronucleosides of formula (II), and physiologically acceptable slats thereof, in particular, the β-enriched anomer of gemcitabine hydrochloride of formula (IIb) in purity of >99% is provided through utilization of a novel trichloroacetimidate of formula (I).

Abstract translation: 本发明提供高度立体选择性，简单和经济的糖基化方法，其用于制备富含β-端基异构体的2-DIO-2 1，1/2 SUP 式（II）的-D-呋喃核糖二基二氟核苷及其生理学上可接受的盐，特别是纯度> 99％的式（IIb）的吉西他滨盐酸盐的β-富集的端基异构体通过使用式（II）的新型三氯乙酰亚氨酸酯 （一世）。

公开(公告)号：US20230041538A1

公开(公告)日：2023-02-09

申请号：US17378663

申请日：2021-07-17

Applicant: AKSHAY KANT CHATURVEDI ,  BIJAN KUMAR PANDA ,  AMIT KUMAR ,  DEEPALI CHATURVEDI

Inventor： AKSHAY KANT CHATURVEDI ,  BIJAN KUMAR PANDA ,  AMIT KUMAR ,  DEEPALI CHATURVEDI

IPC: C07D487/04 ,  C07C273/18

Abstract: The present invention provides a new process for preparation of imidazo-tetrazine class of chemical entity useful as anticancer agent. The present invention provides a commercially and economically viable process for preparation of Temozolomide of formula (VI). Present invention also relates to an intermediate compound of formula (III) and its preparation useful in the process for preparing Temozolomide.