发明授权
- 专利标题： Method of identifying inhibitors of DHODH
- 专利标题（中）： 鉴定DHODH抑制剂的方法
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申请号： US10736739申请日： 2004-11-10
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公开(公告)号： US07247736B2公开(公告)日： 2007-07-24
- 发明人: Johann Leban , Bernd Kramer , Roland Baumgartner , Katharina Aulinger-Fuchs , Stefan Tasler
- 申请人： Johann Leban , Bernd Kramer , Roland Baumgartner , Katharina Aulinger-Fuchs , Stefan Tasler
- 申请人地址： DE Martinsried
- 专利权人： 4SC AG
- 当前专利权人： 4SC AG
- 当前专利权人地址： DE Martinsried
- 代理机构： Womble, Carlyle, Sandridge & Rice, PLLC
- 主分类号： C07D333/10
- IPC分类号： C07D333/10 ; C07C235/84
摘要：
The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.
公开/授权文献
- US20070027193A1 Method of identifying inhibitors of DHODH 公开/授权日：2007-02-01
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