Method of identifying inhibitors of DHODH
    2.
    发明授权
    Method of identifying inhibitors of DHODH 有权
    鉴定DHODH抑制剂的方法

    公开(公告)号:US07247736B2

    公开(公告)日:2007-07-24

    申请号:US10736739

    申请日:2004-11-10

    IPC分类号: C07D333/10 C07C235/84

    摘要: The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.

    摘要翻译: 本发明提供能够结合DHODH的泛素结合位点的化合物,其含有非芳香族环系统作为核心结构,能够与DHODH的泛素结合位点的亚位点2或3的结构元件相互作用的基团和 能够与DHODH的泛醌结合位点的亚位点1的结构元件疏水相互作用的基团。 此外,本发明提供能够结合含有芳环系统作为核心结构的DHODH的泛素结合位点的化合物,能够与泛醌结合的亚位点3的残基His 56和/或Tyr 356相互作用的基团 DHODH的位点和能够与DHODH的泛素结合位点的亚位点1的结构元件疏水相互作用的基团。

    CONTROLLABLE DRIVE FOR A MOTOR VEHICLE, IN PARTICULAR FOR A COOLANT PUMP
    3.
    发明申请
    CONTROLLABLE DRIVE FOR A MOTOR VEHICLE, IN PARTICULAR FOR A COOLANT PUMP 有权
    适用于汽车的可控驱动,特别适用于冷却液泵

    公开(公告)号:US20070110594A1

    公开(公告)日:2007-05-17

    申请号:US11555937

    申请日:2006-11-02

    IPC分类号: F04B9/00

    摘要: A controllable drive (1) suitable for a motor vehicle coolant pump (2) comprises a rotatably mounted shaft (5), a driven member (7) which is rotationally fixedly mounted on the shaft (5), a driving member (9) which is mounted so as to be rotatable relative to the shaft (5), and a coupling region (7/8) which is arranged between the driving and driven members (9, 7) and holds a viscous fluid. At least one first flow path and at least one second flow path connect a fluid reservoir to the coupling region (7/8), and an actuation device (11a, 11b, 12, 13, 14) changes at least one passage opening of at least one flow path. A coupling housing (8, 8a, 8b) is connected to the driving member (9), and the actuator (14) is arranged within the coupling housing (8, 8a, 8b).

    摘要翻译: 适用于机动车辆冷却剂泵(2)的可控驱动器(1)包括可旋转地安装的轴(5),被旋转地固定地安装在轴(5)上的从动构件(7),驱动构件(9) 安装成能够相对于轴(5)​​旋转,以及联接区域(7/8),其布置在驱动构件和被驱动构件(9,7)之间并保持粘性流体。 至少一个第一流动路径和至少一个第二流动路径将流体储存器连接到联接区域(7/8),并且致动装置(11a,11b,12,13,14)改变至少一个通道开口 的至少一个流动路径。 联接壳体(8,8a,8b)连接到驱动构件(9),并且致动器(14)布置在联接壳体(8,8a,8b)内。

    Regulatable drive for a motor vehicle component
    5.
    发明授权
    Regulatable drive for a motor vehicle component 有权
    机动车部件的可调节驱动

    公开(公告)号:US07828529B2

    公开(公告)日:2010-11-09

    申请号:US11062754

    申请日:2005-02-23

    IPC分类号: F04B49/00 F04B17/00

    摘要: A regulatable drive for a motor vehicle, in particular for a water pump in a motor vehicle, has a rotatably mounted shaft, on which is located a rotatably mounted drive member and a rotationally fixed driven member. Between the drive member and driven member, a coupling region is defined, which can receive a viscous fluid for selectively coupling the drive member and driven member. The regulatable drive includes at least one first and at least one second flow path, which connect a fluid storage space to the coupling region, and it has a device which can be varied in its position by means of at least one actuator and which varies at least one passage orifice of at least one of the flow paths.

    摘要翻译: 用于机动车辆,特别是机动车辆中的水泵的可调节驱动器具有可旋转地安装的轴,其上设置有可旋转地安装的驱动构件和旋转固定的从动构件。 在驱动构件和从动构件之间限定了联接区域,其可以容纳用于选择性地联接驱动构件和被驱动构件的粘性流体。 可调节驱动器包括至少一个第一和至少一个第二流动路径,其将流体存储空间连接到联接区域,并且其具有可以通过至少一个致动器在其位置变化的装置,并且其在 至少一个流路的至少一个通道孔。

    Connector plug and mating plug
    7.
    发明申请

    公开(公告)号:US20070020973A1

    公开(公告)日:2007-01-25

    申请号:US11488125

    申请日:2006-07-18

    IPC分类号: H01R13/648

    摘要: The invention concerns a coaxial connector plug and mating plug in which the connector plug has a connector housing that is open at the front end for plugging in the mating plug and contains a canal holding an insulated internal conductor contact, with a clamp sleeve and a sliding sleeve that can be moved axially to mechanically connect the connector housing with the mating plug, wherein the sliding sleeve surrounds the clamp sleeve in the operating position and exerts on it a force directed radially inward in the operating position, and wherein the clamp sleeve can be made to rest against the mating plug at a clamp surface, and wherein an outer conductor contact surface of the mating plug can be clamped axially against an outer conductor contact surface of the connector plug. The purpose of the invention is to create a connector plug of the sort described above, where an outer conductor contact surface of the mating plug can be axially clamped against an outer conductor contact surface of the connector plug, independent of the shape of the clamp surface, in other words, even if the clamp surface is perpendicular to the longitudinal axis of the mating plug. This purpose is achieved in that the clamp sleeve (8) has an end section (15) with a part (15a) extending diagonally outward followed by a part (15b) extending diagonally inward and backward, wherein an axial force component (Fa) is exerted in the operating position by the clamp sleeve (8) on the clamp surface (13) via the part (15b) extending backward and in that the clamp sleeve (8) has a widening part (12) between the connector plug and the end section (15) followed by a narrowing part (12a).

    Controllable drive for a motor vehicle, in particular for a coolant pump
    9.
    发明授权
    Controllable drive for a motor vehicle, in particular for a coolant pump 有权
    机动车辆的可控制驱动装置,特别是冷却液泵

    公开(公告)号:US07914264B2

    公开(公告)日:2011-03-29

    申请号:US11555937

    申请日:2006-11-02

    IPC分类号: F04B49/03 F04B9/00 F16D31/00

    摘要: A controllable drive (1) suitable for a motor vehicle coolant pump (2) comprises a rotatably mounted shaft (5), a driven member (7) which is rotationally fixedly mounted on the shaft (5), a driving member (9) which is mounted so as to be rotatable relative to the shaft (5), and a coupling region (7/8) which is arranged between the driving and driven members (9, 7) and holds a viscous fluid. At least one first flow path and at least one second flow path connect a fluid reservoir to the coupling region (7/8), and an actuation device (11a, 11b, 12, 13, 14) changes at least one passage opening of at least one flow path. A coupling housing (8, 8a, 8b) is connected to the driving member (9), and the actuator (14) is arranged within the coupling housing (8, 8a, 8b).

    摘要翻译: 适用于机动车辆冷却剂泵(2)的可控驱动器(1)包括可旋转地安装的轴(5),被旋转地固定地安装在轴(5)上的从动构件(7),驱动构件(9) 安装成能够相对于轴(5)​​旋转,以及联接区域(7/8),其布置在驱动构件和被驱动构件(9,7)之间并保持粘性流体。 至少一个第一流动路径和至少一个第二流动路径将流体储存器连接到联接区域(7/8),并且致动装置(11a,11b,12,13,14)改变至少一个通道开口 至少一个流路。 联接壳体(8,8a,8b)连接到驱动构件(9),并且致动器(14)布置在联接壳体(8,8a,8b)内。

    Method of Identifying Inhibitors of DHODH
    10.
    发明申请
    Method of Identifying Inhibitors of DHODH 审中-公开
    鉴定DHODH抑制剂的方法

    公开(公告)号:US20070224672A1

    公开(公告)日:2007-09-27

    申请号:US11626140

    申请日:2007-01-23

    IPC分类号: C12N9/02 G06F19/00

    摘要: The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.

    摘要翻译: 本发明提供能够结合DHODH的泛素结合位点的化合物,其含有非芳香族环系统作为核心结构,能够与DHODH的泛素结合位点的亚位点2或3的结构元件相互作用的基团和 能够与DHODH的泛醌结合位点的亚位点1的结构元件疏水相互作用的基团。 此外,本发明提供能够结合含有芳环系统作为核心结构的DHODH的泛素结合位点的化合物,能够与泛醌结合的亚位点3的残基His 56和/或Tyr 356相互作用的基团 DHODH的位点和能够与DHODH的泛素结合位点的亚位点1的结构元件疏水相互作用的基团。