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    Method of Identifying Inhibitors of DHODH
    1.
    发明申请
    Method of Identifying Inhibitors of DHODH 审中-公开
    鉴定DHODH抑制剂的方法

    公开(公告)号：US20070224672A1

    公开(公告)日：2007-09-27

    申请号：US11626140

    申请日：2007-01-23

    申请人： Johann Leban ,  Bernd Kramer ,  Roland Baumgartner ,  Katharina Aulinger-Fuchs ,  Stefan Tasler

    发明人： Johann Leban ,  Bernd Kramer ,  Roland Baumgartner ,  Katharina Aulinger-Fuchs ,  Stefan Tasler

    IPC分类号： C12N9/02 ,  G06F19/00

    CPC分类号： A61K31/401 ,  A61K31/44 ,  C07C233/60 ,  C07C2601/10 ,  C07D333/24 ,  Y02A50/411

    摘要： The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.

    摘要翻译： 本发明提供能够结合DHODH的泛素结合位点的化合物，其含有非芳香族环系统作为核心结构，能够与DHODH的泛素结合位点的亚位点2或3的结构元件相互作用的基团和 能够与DHODH的泛醌结合位点的亚位点1的结构元件疏水相互作用的基团。 此外，本发明提供能够结合含有芳环系统作为核心结构的DHODH的泛素结合位点的化合物，能够与泛醌结合的亚位点3的残基His 56和/或Tyr 356相互作用的基团 DHODH的位点和能够与DHODH的泛素结合位点的亚位点1的结构元件疏水相互作用的基团。

    Method of identifying inhibitors of DHODH
    2.
    发明授权
    Method of identifying inhibitors of DHODH 有权
    鉴定DHODH抑制剂的方法

    公开(公告)号：US07247736B2

    公开(公告)日：2007-07-24

    申请号：US10736739

    申请日：2004-11-10

    申请人： Johann Leban ,  Bernd Kramer ,  Roland Baumgartner ,  Katharina Aulinger-Fuchs ,  Stefan Tasler

    发明人： Johann Leban ,  Bernd Kramer ,  Roland Baumgartner ,  Katharina Aulinger-Fuchs ,  Stefan Tasler

    IPC分类号： C07D333/10 ,  C07C235/84

    CPC分类号： A61K31/401 ,  A61K31/44 ,  C07C233/60 ,  C07C2601/10 ,  C07D333/24 ,  Y02A50/411

    摘要： The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.

    摘要翻译： 本发明提供能够结合DHODH的泛素结合位点的化合物，其含有非芳香族环系统作为核心结构，能够与DHODH的泛素结合位点的亚位点2或3的结构元件相互作用的基团和 能够与DHODH的泛醌结合位点的亚位点1的结构元件疏水相互作用的基团。 此外，本发明提供能够结合含有芳环系统作为核心结构的DHODH的泛素结合位点的化合物，能够与泛醌结合的亚位点3的残基His 56和/或Tyr 356相互作用的基团 DHODH的位点和能够与DHODH的泛素结合位点的亚位点1的结构元件疏水相互作用的基团。