发明授权
US07250177B2 Multiblock biodegradable hydrogels for drug delivery and tissue treatment
有权
用于药物递送和组织治疗的多嵌段可生物降解水凝胶
- 专利标题： Multiblock biodegradable hydrogels for drug delivery and tissue treatment
- 专利标题（中）： 用于药物递送和组织治疗的多嵌段可生物降解水凝胶
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申请号： US11158565申请日： 2005-06-22
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公开(公告)号： US07250177B2公开(公告)日： 2007-07-31
- 发明人: Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
- 申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
- 申请人地址： US MA Cambridge
- 专利权人： Genzyme Corporation
- 当前专利权人： Genzyme Corporation
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; C08L51/00 ; C08L53/00
摘要：
Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.