发明授权
- 专利标题: MR-method for the in vivo measurement of temperature or pH-value by means of a hyperpolarised contrast agent
- 专利标题(中): 用于通过超极化造影剂体内测量温度或pH值的MR方法
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申请号: US10240754申请日: 2001-04-12
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公开(公告)号: US07251519B2公开(公告)日: 2007-07-31
- 发明人: Oskar Axelsson , Jan Henrik Ardenkjaer-Larsen , Sven Månsson , Stefan Petersson , Ib Leunbach
- 申请人: Oskar Axelsson , Jan Henrik Ardenkjaer-Larsen , Sven Månsson , Stefan Petersson , Ib Leunbach
- 申请人地址: NO Oslo
- 专利权人: GE Healthcare AS
- 当前专利权人: GE Healthcare AS
- 当前专利权人地址: NO Oslo
- 代理商 Robert F. Chisholm
- 国际申请: PCT/GB01/01685 WO 20010412
- 国际公布: WO01/79875 WO 20011025
- 主分类号: A61B5/05
- IPC分类号: A61B5/05
摘要:
The present invention provides a method of MR investigation of a sample, said method comprising: (i) nuclear spin polarizing a high T1 MR imaging agent which contains in its molecular structure at least two hyperpolarisable nuclei within the same molecule, the frequency difference between the two resonance lines from said nuclei, δυ, being dependent upon either the temperature or the pH of said sample; (ii) administering the nuclear spin polarized MR imaging agent to said sample; (iii) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in said MR imaging agent; and (iv) detecting and manipulating magnetic resonance signals from said sample using a single-shot RARE acquisition sequence with shifted data acquisition.