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    MR-method for the in vivo measurement of temperature or pH-value by means of a hyperpolarised contrast agent
    1.
    发明授权
    MR-method for the in vivo measurement of temperature or pH-value by means of a hyperpolarised contrast agent 有权
    用于通过超极化造影剂体内测量温度或pH值的MR方法

    公开(公告)号：US07251519B2

    公开(公告)日：2007-07-31

    申请号：US10240754

    申请日：2001-04-12

    申请人： Oskar Axelsson ,  Jan Henrik Ardenkjaer-Larsen ,  Sven Månsson ,  Stefan Petersson ,  Ib Leunbach

    发明人： Oskar Axelsson ,  Jan Henrik Ardenkjaer-Larsen ,  Sven Månsson ,  Stefan Petersson ,  Ib Leunbach

    IPC分类号： A61B5/05

    CPC分类号： G01R33/5601 ,  G01R33/4804 ,  Y10T436/24

    摘要： The present invention provides a method of MR investigation of a sample, said method comprising: (i) nuclear spin polarizing a high T1 MR imaging agent which contains in its molecular structure at least two hyperpolarisable nuclei within the same molecule, the frequency difference between the two resonance lines from said nuclei, δυ, being dependent upon either the temperature or the pH of said sample; (ii) administering the nuclear spin polarized MR imaging agent to said sample; (iii) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in said MR imaging agent; and (iv) detecting and manipulating magnetic resonance signals from said sample using a single-shot RARE acquisition sequence with shifted data acquisition.

    摘要翻译： 本发明提供了一种样品的MR研究方法，所述方法包括：（i）使自旋极化的高T1MR成像剂，其在其分子结构中包含在相同分子内的至少两个超极化核， 来自所述核的两条共振线，δupsilon，取决于所述样品的温度或pH值; （ii）向所述样品施用核自旋极化MR成像剂; （iii）将所述样品暴露于以选定的频率激发所述MR成像剂中的核自旋跃迁的辐射; 和（iv）使用具有移位数据采集的单次RARE获取序列检测和操纵来自所述样本的磁共振信号。

    Method of magnetic resonance imaging
    2.
    发明授权
    Method of magnetic resonance imaging 失效
    磁共振成像方法

    公开(公告)号：US06453188B1

    公开(公告)日：2002-09-17

    申请号：US09333910

    申请日：1999-06-16

    申请人： Jan Henrik Ardenkjaer-Larsen ,  Oskar Axelsson ,  Klaes Golman ,  Georg Hansson ,  Ib Leunbach ,  Stefan Petersson ,  Lars-Goran Wistrand

    发明人： Jan Henrik Ardenkjaer-Larsen ,  Oskar Axelsson ,  Klaes Golman ,  Georg Hansson ,  Ib Leunbach ,  Stefan Petersson ,  Lars-Goran Wistrand

    IPC分类号： A61B505

    CPC分类号： G01R33/5601

    摘要： The invention relates to a method of magnetic imaging (MR) of a living sample comprising the steps of hyperpolarizing a hyperpolarizable gas ex-vivo and transferring the nuclear polarization from the hyperpolarized gas to the nuclei of an MR imaging agent, that is not hyperpolarizable, that is exposed to a uniform magnetic field and that is introduced in contact to the hyperpolarizable gas, separating the hyperpolarizable gas from the MR imaging agent, administering the MR imaging agent to the living sample, exciting NMR transitions in the nuclei of the imaging agent and detecting an NMR signal thereof.

    摘要翻译： 本发明涉及一种活体样品的磁成像（MR）方法，包括以下步骤：离子超极化超极化气体，并将核极化从超极化气体转移到MR成像剂的核，其不是超极化的， 暴露于均匀的磁场并且与超极化气体接触引入，将超极化气体与MR成像剂分离，将MR成像剂施用于活体样品，在显像剂的细胞核中激发NMR转变，以及 检测其NMR信号。

    Overhauser magnetic resonance imaging (ORMI) method comprising ex vivo polarization of a magnetic resonance (MR) imaging agent
    4.
    发明授权
    Overhauser magnetic resonance imaging (ORMI) method comprising ex vivo polarization of a magnetic resonance (MR) imaging agent 有权
    Overhauser磁共振成像（ORMI）方法包括磁共振（MR）成像剂的离体极化

    公开(公告)号：US06311086B1

    公开(公告)日：2001-10-30

    申请号：US09460094

    申请日：1999-12-13

    申请人： Jan Henrik Ardenkjaer-Larsen ,  Klaes Golman ,  Georg Hansson ,  Ib Leunbach ,  Stefan Petersson ,  Lars-Goran Wistrand ,  Oskar Axelsson

    发明人： Jan Henrik Ardenkjaer-Larsen ,  Klaes Golman ,  Georg Hansson ,  Ib Leunbach ,  Stefan Petersson ,  Lars-Goran Wistrand ,  Oskar Axelsson

    IPC分类号： A61B505

    CPC分类号： A61K49/10 ,  A61K49/08 ,  A61K49/18 ,  A61K49/20 ,  G01R33/5601 ,  G01R33/62

    摘要： This invention provides a method of MR investigation of a sample, the method comprising: (i) placing in a uniform magnetic field a composition comprising an OMRI contrast agent and an MR imaging agent containing nuclei (MR imaging nuclei) capable of emitting magnetic resonance signals (e.g. the primary magnetic field B0) and capable of exhibiting a T1 relaxation time of 6 s or more (at 37° C. in D2O in a field of 7T); (ii) exposing the composition to a first radiation of a frequency selected to excite electron spin transitions in the OMRI contrast agent; (iii) optionally but preferably separating the whole, substantially the whole, or a portion of said OMRI contrast agent from said MR imaging agent; (iv) administering said MR imaging agent to said sample, (v) exposing the sample to a second radiation of a frequency selected to excite nuclear spin transitions; (vi) detecting magnetic resonance signals from the sample; and (vii) optionally, generating an image or dynamic flow data from the detected signals.

    摘要翻译： 本发明提供了一种样品的MR研究方法，该方法包括：（i）在均匀的磁场中放置包含OMRI造影剂和含有能够发射磁共振信号的核（MR成像核）的MR成像剂的组合物 （例如初级磁场B0），并且能够表现出6秒以上的T1弛豫时间（在7T的场中在D2O中为37℃）; （ii）将组合物暴露于在OMRI造影剂中激发电子自旋跃迁的频率的第一辐射; （iii）任选地但优选地将所述OMRI造影剂的全部，基本上全部或一部分与所述MR成像剂分离; （iv）向所述样品施用所述MR成像剂，（v）将所述样品暴露于选定为激发核自旋转变的频率的第二辐射; （vi）检测来自样品的磁共振信号; 和（vii）可选地，从检测到的信号生成图像或动态流量数据。

    Multidimensional NMR spectroscopy of a hyperpolarized sample
    8.
    发明授权
    Multidimensional NMR spectroscopy of a hyperpolarized sample 有权
    超极化样品的多维NMR光谱

    公开(公告)号：US07550970B2

    公开(公告)日：2009-06-23

    申请号：US10553381

    申请日：2004-04-13

    申请人： Rolf Servin ,  Jan Henrik Ardenkjaer-Larsen ,  Haukur Johannesson ,  Maurice Goldman ,  Jan Wolber

    发明人： Rolf Servin ,  Jan Henrik Ardenkjaer-Larsen ,  Haukur Johannesson ,  Maurice Goldman ,  Jan Wolber

    IPC分类号： G01V3/00

    CPC分类号： G01R33/4633 ,  G01R33/62

    摘要： The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receives hyperpolarization; performing NMR spectroscopy on the sample with the use of sequences of rf-pulses, wherein the pulse sequences comprises at least two rf-pulses, either on the same nuclei or on different nuclei, and wherein the pulse sequence is adapted for a hyperpolarized sample; and analyzing at least two of the NMR spectra to obtain a characterization of the sample, or to obtain an interim result to be used in the NMR spectroscopy step.

    摘要翻译： 本发明涉及适用于超极化样品的核磁共振（NMR）光谱的方法。 所述方法包括使用DNP超极化样品的步骤，其中至少一部分NMR活性核接受超极化; 使用rf脉冲序列对样本进行NMR光谱分析，其中所述脉冲序列包括在同一核上或不同核上的至少两个rf脉冲，并且其中所述脉冲序列适用于超极化样品; 并分析至少两个NMR光谱以获得样品的表征，或获得在NMR光谱步骤中使用的中间结果。