Invention Grant
US07253165B2 Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
失效
可用作D4拮抗剂的苯并异恶唑基 - ,吡啶并恶唑基和苯并噻吩基 - 苯氧基衍生物
- Patent Title: Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
- Patent Title (中): 可用作D4拮抗剂的苯并异恶唑基 - ,吡啶并恶唑基和苯并噻吩基 - 苯氧基衍生物
-
Application No.: US10844245Application Date: 2004-05-12
-
Publication No.: US07253165B2Publication Date: 2007-08-07
- Inventor: Gregory M. Shutske , James A. Hendrix , John G. Jurcak , Brian S. Freed , Nicholas J. Hrib , John D. Tomer, IV , Reda G. Hanna
- Applicant: Gregory M. Shutske , James A. Hendrix , John G. Jurcak , Brian S. Freed , Nicholas J. Hrib , John D. Tomer, IV , Reda G. Hanna
- Applicant Address: US NJ Bridgewater
- Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee Address: US NJ Bridgewater
- Agent Barbara E. Kurys
- Main IPC: C07D498/02
- IPC: C07D498/02 ; A61K31/5377 ; A61K31/496

Abstract:
The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.
Public/Granted literature
- US20050107377A1 Benzisoxazolyl-,pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists Public/Granted day:2005-05-19
Information query