发明授权
US07270800B2 Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
有权
硫磺衍生物用于阿尔茨海默病的止血诊断和体内成像和预防淀粉样蛋白沉积
- 专利标题： Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
- 专利标题（中）： 硫磺衍生物用于阿尔茨海默病的止血诊断和体内成像和预防淀粉样蛋白沉积
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申请号： US10388173申请日： 2003-03-14
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公开(公告)号： US07270800B2公开(公告)日： 2007-09-18
- 发明人: William E. Klunk , Chester A. Mathis, Jr. , Yanming Wang
- 申请人： William E. Klunk , Chester A. Mathis, Jr. , Yanming Wang
- 申请人地址： US PA Pittsburgh
- 专利权人： University of Pittsburgh
- 当前专利权人： University of Pittsburgh
- 当前专利权人地址： US PA Pittsburgh
- 代理机构： Foley & Lardner LLP
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; A61M36/14
摘要：
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
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