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    THIOFLAVIN DERIVATES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION
    2.
    发明申请
    THIOFLAVIN DERIVATES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION 审中-公开
    用于阿尔茨海默病和体内成像和预防淀粉样沉积症的手术诊断中的三唑衍生物

    公开(公告)号：US20120095235A1

    公开(公告)日：2012-04-19

    申请号：US13310243

    申请日：2011-12-02

    申请人： William E. KLUNK ,  Chester A. Mathis, JR. ,  Yanming Wang

    发明人： William E. KLUNK ,  Chester A. Mathis, JR. ,  Yanming Wang

    IPC分类号： C07D417/10 ,  C07D277/64

    CPC分类号： A61K31/5415 ,  A61K31/428 ,  A61K51/0497 ,  C07B2200/05 ,  C07D277/64 ,  C07D277/66

    摘要： This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.

    摘要翻译： 本发明涉及新型硫黄素衍生物，在例如具有神经炎斑块的患者的体内成像中使用衍生物的方法，包含硫代黄素衍生物的药物组合物和合成该化合物的方法。 该化合物特别用于诊断和治疗患有神经炎斑块积聚的疾病的患者。 疾病状态或疾病包括但不限于阿尔茨海默病，家族性阿尔茨海默氏病，唐氏综合征和载脂蛋白E4等位基因的纯合子。

    DETECTION AND QUANTIFICATION OF ABASIC SITE FORMATION IN VIVO
    5.
    发明申请
    DETECTION AND QUANTIFICATION OF ABASIC SITE FORMATION IN VIVO 有权
    检测和定量生物体内的生物体形成

    公开(公告)号：US20100111861A1

    公开(公告)日：2010-05-06

    申请号：US12610871

    申请日：2009-11-02

    申请人： Lili Liu ,  Yanming Wang ,  Stanton Gerson

    发明人： Lili Liu ,  Yanming Wang ,  Stanton Gerson

    IPC分类号： A61K51/04

    CPC分类号： A61K51/0406 ,  A61K49/0008 ,  G01N33/5011

    摘要： A method of measuring the efficacy of an anticancer agent in generating abasic (AP) sites in DNA of cancer cells of a subject includes administering to the subject an anticancer agent that generates AP sites in at least one cancer cell and an AP endonuclease inhibitor probe. The AP endonuclease inhibitor probe includes a detection moiety for detecting the probe in the subject. The amount of probe bound to cancer cells of the subject is then measured. The amount of probe bound to cancer cells of the subject is indicative of efficacy of the anticancer agent in generating AP sites in cancer cells of the subject.

    摘要翻译： 测量抗癌剂在产生受试者的癌细胞的DNA中的脱碱性（AP）位点的功效的方法包括向受试者施用在至少一种癌细胞中产生AP位点的抗癌剂和AP内切核酸酶抑制剂探针。 AP内切核酸酶抑制剂探针包括用于检测受试者中的探针的检测部分。 然后测量与受试者的癌细胞结合的探针的量。 与受试者的癌细胞结合的探针的量指示抗癌剂在产生受试者的癌细胞中的AP位点的功效。

    THIOFLAVIN DERIVATIVES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMERS DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION
    10.
    发明申请
    THIOFLAVIN DERIVATIVES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMERS DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION 审中-公开
    用于治疗ALZHEIMERS疾病和VIVO成像和防止淀粉样沉积的ANTEMORTEM诊断中的三氟衍生物

    公开(公告)号：US20080154042A1

    公开(公告)日：2008-06-26

    申请号：US12046070

    申请日：2008-03-11

    申请人： William E. KLUNK ,  Chester A. MATHIS ,  Yanming WANG

    发明人： William E. KLUNK ,  Chester A. MATHIS ,  Yanming WANG

    IPC分类号： C07D277/66 ,  C07D417/02

    CPC分类号： A61K31/5415 ,  A61K31/428 ,  A61K51/0497 ,  C07B2200/05 ,  C07D277/64 ,  C07D277/66

    摘要： This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.

    摘要翻译： 本发明涉及新型硫黄素衍生物，在例如具有神经炎斑块的患者的体内成像中使用衍生物的方法，包含硫代黄素衍生物的药物组合物和合成该化合物的方法。 该化合物特别用于诊断和治疗患有神经炎斑块积聚的疾病的患者。 疾病状态或疾病包括但不限于阿尔茨海默病，家族性阿尔茨海默氏病，唐氏综合征和载脂蛋白E4等位基因的纯合子。