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公开(公告)号：US08691185B2
公开(公告)日：2014-04-08
申请号：US13548014
申请日：2012-07-12
CPC分类号： G01N33/6896 , C07D277/66 , G01N33/60
摘要： This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s).
摘要翻译： 本发明提供苯并噻唑衍生物化合物，包含这些化合物的组合物，制备此类化合物的方法，以及使用这些化合物检测淀粉样蛋白沉积物和用于诊断以淀粉样蛋白沉积为特征的疾病，病症或病症的方法。
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2.发明授权Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition 有权硫磺衍生物用于阿尔茨海默病的止血诊断和体内成像和预防淀粉样蛋白沉积公开(公告)号：US07270800B2
公开(公告)日：2007-09-18
申请号：US10388173
申请日：2003-03-14
CPC分类号： A61K51/0453 , A61K31/428 , A61K51/0497 , C07B2200/05 , C07D277/64 , C07D277/66 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/387
摘要： This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
摘要翻译： 本发明涉及新型硫黄素衍生物，在例如具有神经炎斑块的患者的体内成像中使用衍生物的方法，包含硫代黄素衍生物的药物组合物和合成该化合物的方法。 该化合物特别用于诊断和治疗患有神经炎斑块积聚的疾病的患者。 疾病状态或疾病包括但不限于阿尔茨海默病，家族性阿尔茨海默氏病，唐氏综合征和载脂蛋白E4等位基因的纯合子。
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3.发明授权Thioflavin derivatives for use in the antemortem diagnosis of Alzheimers disease and in vivo imaging and prevention of amyloid deposition 有权硫磺衍生物用于阿尔茨海默病的止血诊断和淀粉样蛋白沉积的体内成像和预防公开(公告)号：US07351401B2
公开(公告)日：2008-04-01
申请号：US10859600
申请日：2004-06-03
CPC分类号： A61K31/5415 , A61K31/428 , A61K51/0497 , C07B2200/05 , C07D277/64 , C07D277/66
摘要： This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
摘要翻译： 本发明涉及新型硫黄素衍生物，在例如具有神经炎斑块的患者的体内成像中使用衍生物的方法，包含硫代黄素衍生物的药物组合物和合成该化合物的方法。 该化合物特别用于诊断和治疗患有神经炎斑块积聚的疾病的患者。 疾病状态或疾病包括但不限于阿尔茨海默病，家族性阿尔茨海默氏病，唐氏综合征和载脂蛋白E4等位基因的纯合子。
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公开(公告)号：US08236282B2
公开(公告)日：2012-08-07
申请号：US12570379
申请日：2009-09-30
CPC分类号： G01N33/6896 , C07D277/66 , G01N33/60
摘要： This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s).
摘要翻译： 本发明提供苯并噻唑衍生物化合物，包含这些化合物的组合物，制备此类化合物的方法，以及使用这些化合物检测淀粉样蛋白沉积物和用于诊断以淀粉样蛋白沉积为特征的疾病，病症或病症的方法。
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5.发明授权Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition 有权用于阿尔茨海默病的止血诊断的硫磺衍生物和淀粉样蛋白沉积的体内成像和预防公开(公告)号：US07854920B2
公开(公告)日：2010-12-21
申请号：US11828554
申请日：2007-07-26
CPC分类号： A61K51/0453 , A61K31/428 , A61K51/0497 , C07B2200/05 , C07D277/64 , C07D277/66 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/387
摘要： This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
摘要翻译： 本发明涉及新型硫黄素衍生物，在例如具有神经炎斑块的患者的体内成像中使用衍生物的方法，包含硫代黄素衍生物的药物组合物和合成该化合物的方法。 该化合物特别用于诊断和治疗患有神经炎斑块积聚的疾病的患者。 疾病状态或疾病包括但不限于阿尔茨海默病，家族性阿尔茨海默氏病，唐氏综合征和载脂蛋白E4等位基因的纯合子。
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6.发明申请THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER`S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION 有权用于阿尔茨海默病和体细胞成像的预防和预防淀粉样沉积物的体内诊断中的三氟衍生物公开(公告)号：US20130236394A1
公开(公告)日：2013-09-12
申请号：US13779063
申请日：2013-02-27
IPC分类号： A61K51/04 , G01N33/68 , C07D277/66
CPC分类号： A61K51/0453 , A61K31/428 , A61K51/0497 , C07B2200/05 , C07D277/64 , C07D277/66 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/387
摘要： This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
摘要翻译： 本发明涉及新型硫黄素衍生物，在例如具有神经炎斑块的患者的体内成像中使用衍生物的方法，包含硫代黄素衍生物的药物组合物和合成该化合物的方法。 该化合物特别用于诊断和治疗患有神经炎斑块积聚的疾病的患者。 疾病状态或疾病包括但不限于阿尔茨海默病，家族性阿尔茨海默氏病，唐氏综合征和载脂蛋白E4等位基因的纯合子。
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公开(公告)号：US08404213B2
公开(公告)日：2013-03-26
申请号：US12971886
申请日：2010-12-17
CPC分类号： A61K51/0453 , A61K31/428 , A61K51/0497 , C07B2200/05 , C07D277/64 , C07D277/66 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/387
摘要： This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
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8.发明申请Method of Diagnosing Prodromal Forms of Diseases Associated With Amyloid Deposition 审中-公开诊断与淀粉样蛋白沉积相关的疾病的原型形式的方法公开(公告)号：US20080286202A1
公开(公告)日：2008-11-20
申请号：US11666084
申请日：2005-07-01
IPC分类号： A61K51/04 , A61K49/00 , A61K49/04 , C07D277/66 , A61K49/10
CPC分类号： A61K51/0478
摘要： A method of identifying a patient as prodromal to a disease associated with amyloid deposition by imaging techniques is provided. In addition, a method of identifying amyloid deposition diseases in patients who present with a dementing disorder of questionable etiology by imaging techniques is provided. The methods discloses substances which are used for imaging and generating data which can be used to determine progress of an asymptomatic patient to a disease associated with amyloid deposition, or to identify amyloid deposition diseases in patients who present with a dementing disorder of questionable etiology.
摘要翻译： 提供了通过成像技术将患者识别为与淀粉样蛋白沉积相关的疾病的前驱性的方法。 另外，提供了一种通过成像技术鉴定出具有可疑病因的痴呆病症的患者中淀粉样蛋白沉积疾病的方法。 该方法公开了用于成像和产生数据的物质，其可以用于确定无症状患者对与淀粉样蛋白沉积相关的疾病的进展，或鉴定存在具有可疑病因的痴呆病症的患者中的淀粉样蛋白沉积疾病。
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9.发明授权Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition 失效烷基，烯基和炔基Chrysamine G衍生物用于阿尔茨海默氏病的止血诊断和体内成像和预防淀粉样蛋白沉积公开(公告)号：US06168776A
公开(公告)日：2001-01-02
申请号：US08837494
申请日：1997-04-18
IPC分类号： A61K4902
CPC分类号： C07D209/48 , A61K49/06 , C07B59/001 , C07B59/002 , C07C63/66 , C07C69/94 , C07D217/24 , C07D221/14 , C07D237/28 , C07D237/32 , C07D257/04 , C07D261/20 , C07D265/02 , C07D265/14 , C07D265/26 , C07D271/10 , C07F7/2208 , C09B23/141 , G01N33/6896 , G01N2800/2821
摘要： Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing non-azo derivatives of Chrysamine G and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using non-azo Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using non-azo Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.
摘要翻译： 描述了作为Chrysamine G的非偶氮衍生物的淀粉样蛋白结合化合物，含有药物组合物的方法，以及使用这些化合物在体内鉴定阿尔茨海默氏症并诊断特征为淀粉样变性的其它病理状态如唐氏综合征的方法。 还描述了含有Chrysamine G的非偶氮衍生物的药物组合物和使用这种组合物在淀粉样变性相关病症中预防细胞变性和淀粉样蛋白诱导的毒性的方法。 还描述了使用非偶氮Chrysamine G衍生物在活组织检查或尸检组织中染色或检测淀粉样蛋白沉积物的方法。 还描述了使用非偶氮Chrysamine G衍生物来量化活组织检查和死后组织匀浆中的淀粉样沉积物的方法。
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10.发明授权Alkyl, alkenyl and alkynyl chrysamine G derivatives for inhibition of cell degeneration and toxicity associated with amyloid deposition 失效用于抑制与淀粉样蛋白沉积相关的细胞变性和毒性的烷基，烯基和炔基奎胺C衍生物
公开(公告)号：US6133259A
公开(公告)日：2000-10-17
申请号：US188200
申请日：1998-11-09
IPC分类号： A61K31/32 , A61K31/60 , A61K31/655 , A61K49/06 , A61M36/14 , C07B59/00 , C07C63/66 , C07C65/03 , C07C65/19 , C07C65/28 , C07C69/88 , C07C69/94 , C07D209/48 , C07D217/24 , C07D221/10 , C07D221/14 , C07D237/28 , C07D237/32 , C07D257/04 , C07D261/20 , C07D265/02 , C07D265/14 , C07D265/26 , C07D271/10 , C07F7/22 , C07F7/24 , C09B23/14 , G01N33/48 , G01N33/68 , A61N25/28
CPC分类号： C07D209/48 , A61K49/06 , C07B59/001 , C07B59/002 , C07C63/66 , C07C69/94 , C07D217/24 , C07D221/14 , C07D237/28 , C07D237/32 , C07D257/04 , C07D261/20 , C07D265/02 , C07D265/14 , C07D265/26 , C07D271/10 , C07F7/2212 , C09B23/141 , G01N33/6896 , G01N2800/2821
摘要： Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing non-azo derivatives of Chrysamine G and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using non-azo Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using non-azo Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.
摘要翻译： 描述了作为Chrysamine G的非偶氮衍生物的淀粉样蛋白结合化合物，含有药物组合物的方法，以及使用这些化合物在体内鉴定阿尔茨海默氏症并诊断特征为淀粉样变性的其它病理状态如唐氏综合征的方法。 还描述了含有Chrysamine G的非偶氮衍生物的药物组合物和使用这种组合物在淀粉样变性相关病症中预防细胞变性和淀粉样蛋白诱导的毒性的方法。 还描述了使用非偶氮Chrysamine G衍生物在活组织检查或尸检组织中染色或检测淀粉样蛋白沉积物的方法。 还描述了使用非偶氮Chrysamine G衍生物来量化活组织检查和死后组织匀浆中的淀粉样沉积物的方法。
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