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发明授权
US07291638B2 3-amido-1,2-benzoisoxazole derivatives, process for preparation, and use thereof 失效
3-酰氨基-1,2-苯并异恶唑衍生物，其制备方法和用途

3-amido-1,2-benzoisoxazole derivatives, process for preparation, and use thereof
摘要：
The present invention relates to 3-amido-1,2-benzoisoxazole derivatives and their salts represented by formula 1, processes for preparation and usees thereof. More particularly, it relates to a method for improving its bioavailability introducing amino acid residue to the amine group of a 3-amido-1,2-benzoisoxazole. The compounds according to the present invention are used as an antagonist against Leukotriene-B-4 receptor, an inhibitor or therapeutics of osteoroposis, thus inhibiting osteolysis and stimulating osteogensis.
摘要（中）：

本发明涉及由式1表示的3-酰氨基-1,2-苯并异恶唑衍生物及其盐，其制备方法及用途。 更具体地说，本发明涉及将氨基酸残基引入3-氨基-1,2-苯并异恶唑的胺基的方法。 根据本发明的化合物用作抗白细胞三烯-B-4受体的拮抗剂，抑制剂或骨质疏松症的治疗剂，从而抑制骨质溶解和刺激骨质疏松。

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