发明授权
US07291641B2 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
失效
具有5个成员的杂环衍生物,其制备及其作为药物的用途
- 专利标题: Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
- 专利标题(中): 具有5个成员的杂环衍生物,其制备及其作为药物的用途
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申请号: US10915001申请日: 2004-08-10
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公开(公告)号: US07291641B2公开(公告)日: 2007-11-06
- 发明人: Pierre-Etienne Chabrier De Lassauniere , Jermiah Harnett , Dennis Bigg , Ann-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau , Zheng Xin Dong
- 申请人: Pierre-Etienne Chabrier De Lassauniere , Jermiah Harnett , Dennis Bigg , Ann-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau , Zheng Xin Dong
- 申请人地址: FR Paris
- 专利权人: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
- 当前专利权人: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
- 当前专利权人地址: FR Paris
- 代理商 Charles A. Muserlian
- 优先权: FR9912643 19991011; FR0010151 20000801; FR0011169 20000901; FR0104943 20010410; FR0201811 20020214
- 主分类号: A61K31/417
- IPC分类号: A61K31/417 ; C07D233/61
摘要:
Thiaxozle, oxazole, imidazole, isoxazole and isoxazoline compounds of the formula wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is selected from the various optionally substituted aromatic radicals defined in the specification, B is hydrogen, alkyl or phenyl, R1 and R2 are independently hydrogen, alkyl or cycloalkyl or R1 and R2 taken together with the carbon atom which carries them, form a carbocycle with 3 to 7 members and Ω is —NH46R47 or —OR48, R46 and R47 are independently hydrogen, alkyl, cycloalkyl or —(CH2)kCOOR51, R51 is alkyl or haloalkyl and R48 is hydrogen or alkyl having advantageous pharmacological properties which allow their use in therapeutics, for treating neurodegenerative disorders or pain.
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