-
1.发明申请Derivatives of heterocycles with 5 members, their preparation and their use as medicaments 失效具有5个成员的杂环衍生物，其制备及其作为药物的用途公开(公告)号：US20050038087A1
公开(公告)日：2005-02-17
申请号：US10915001
申请日：2004-08-10
申请人： Pierre-Etienne Chabrier De Lassauniere , Jermiah Harnett , Dennis Bigg , Ann-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau , Zheng Xin Dong
发明人： Pierre-Etienne Chabrier De Lassauniere , Jermiah Harnett , Dennis Bigg , Ann-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau , Zheng Xin Dong
IPC分类号： A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , A61P25/08 , A61P25/28 , A61P29/00 , C07D233/50 , C07D233/54 , C07D261/04 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/34 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14 , A61K31/425 , A61K31/4164
CPC分类号： C07D233/64 , A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , C07D233/50 , C07D261/04 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/34 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl or R1 and R2, taken together with the carbon atom which carries them, form a carbocycle with 3 to 7 members and Ω is —NR46R47 or —OR48, R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.
摘要翻译： 本发明涉及噻唑，恶唑，咪唑，异恶唑和其中Het为噻唑，恶唑，咪唑，异恶唑或异恶唑啉的通式（I）的异恶唑啉衍生物，n为0至6的整数，A特别选自各种任选取代的 芳基，B特别是氢，烷基或苯基，R 1和R 2独特地独立地表示氢，烷基或环烷基或R 1和R 2与携带它们的碳原子一起， 形成具有3至7个成员的碳环，并且ω是-NR 46 R 47或-OR 48，R 46和R 47独立地是氢，烷基，环烷基或 - （CH 2）k -COOR 51，R 51特别是烷基或卤代烷基，R 48特别是氢或烷基。 这些化合物具有有利的药理学性质，其允许其用于治疗学，特别是用于治疗神经变性疾病或疼痛。
-
2.发明授权Derivatives of heterocycles with 5 members, their preparation and their use as medicaments 失效具有5个成员的杂环衍生物，其制备及其作为药物的用途公开(公告)号：US07291641B2
公开(公告)日：2007-11-06
申请号：US10915001
申请日：2004-08-10
申请人： Pierre-Etienne Chabrier De Lassauniere , Jermiah Harnett , Dennis Bigg , Ann-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau , Zheng Xin Dong
发明人： Pierre-Etienne Chabrier De Lassauniere , Jermiah Harnett , Dennis Bigg , Ann-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau , Zheng Xin Dong
IPC分类号： A61K31/417 , C07D233/61
CPC分类号： C07D233/64 , A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , C07D233/50 , C07D261/04 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/34 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Thiaxozle, oxazole, imidazole, isoxazole and isoxazoline compounds of the formula wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is selected from the various optionally substituted aromatic radicals defined in the specification, B is hydrogen, alkyl or phenyl, R1 and R2 are independently hydrogen, alkyl or cycloalkyl or R1 and R2 taken together with the carbon atom which carries them, form a carbocycle with 3 to 7 members and Ω is —NH46R47 or —OR48, R46 and R47 are independently hydrogen, alkyl, cycloalkyl or —(CH2)kCOOR51, R51 is alkyl or haloalkyl and R48 is hydrogen or alkyl having advantageous pharmacological properties which allow their use in therapeutics, for treating neurodegenerative disorders or pain.
摘要翻译： 噻唑，恶唑，咪唑，异恶唑和异恶唑啉化合物，其中Het是噻唑，恶唑，咪唑，异恶唑或异恶唑啉，n是0至6的整数，A选自说明书中定义的各种任选取代的芳族基， B是氢，烷基或苯基，R 1和R 2独立地是氢，烷基或环烷基或R 1和R 2 与携带它们的碳原子一起形成具有3至7个成员的碳环，并且Ω是-NH 46和/或 48，R 46和R 47独立地是氢，烷基，环烷基或 - （CH 2 CH 2） C 51，R 51是烷基或卤代烷基，R 48是具有有利药理学性质的氢或烷基，其允许它们用于治疗学 用于治疗神经变性疾病或疼痛。
-
3.发明授权Derivatives of heterocycles with 5 members, their preparation and their use as medicaments 有权具有5个成员的杂环衍生物，其制备及其作为药物的用途公开(公告)号：US08288560B2
公开(公告)日：2012-10-16
申请号：US13053092
申请日：2011-03-21
申请人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
发明人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
IPC分类号： C07D277/28
CPC分类号： C07D277/28 , A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , C07D233/64 , C07D261/04 , C07D263/32 , C07D277/24 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06
摘要： The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl and Ω is —NR46R47 or —OR48, R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.
摘要翻译： 本发明涉及噻唑，恶唑，咪唑，异恶唑和其中Het为噻唑，恶唑，咪唑，异恶唑或异恶唑啉的通式（I）的异恶唑啉衍生物，n为0至6的整数，A特别选自各种任选取代的 芳基，B特别是氢，烷基或苯基，R 1和R 2特别独立地是氢，烷基或环烷基，和OHgr; 是-NR46R47或-OR48，R46和R47独特地是氢，烷基，环烷基或 - （CH2）k-COOR51，R51尤其是烷基或卤代烷基，R48特别是氢或烷基。 这些化合物具有有利的药理学性质，其允许其用于治疗学，特别是用于治疗神经变性疾病或疼痛。
-
4.发明申请Derivatives of heterocycles with 5 members, their preparation and their use as medicaments 有权具有5个成员的杂环衍生物，其制备及其作为药物的用途公开(公告)号：US20080146627A1
公开(公告)日：2008-06-19
申请号：US12001439
申请日：2007-12-11
申请人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
发明人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
IPC分类号： A61K31/426 , C07D277/02
CPC分类号： C07D277/28 , A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , C07D233/64 , C07D261/04 , C07D263/32 , C07D277/24 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06
摘要： The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl and Q is —NR46R47 or —OR48, R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl.These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.
摘要翻译： 本发明涉及噻唑，恶唑，咪唑，异恶唑和其中Het为噻唑，恶唑，咪唑，异恶唑或异恶唑啉的通式（I）的异恶唑啉衍生物，n为0至6的整数，A特别选自各种任选取代的 芳基，B特别是氢，烷基或苯基，R 1和R 2特别独立地为氢，烷基或环烷基，Q为-NR 46， 或者-OR 48，R 46和R 47非常独立地是氢，烷基，环烷基 或 - （CH 2）2 - ， - OR 51，R 51特别是烷基或卤代烷基，R SUP 特别是氢或烷基。 这些化合物具有有利的药理学性质，其允许其用于治疗学，特别是用于治疗神经变性疾病或疼痛。
-
5.发明授权Derivatives of heterocycles with 5 members, their preparation and their use as medicaments 有权具有5个成员的杂环衍生物，其制备及其作为药物的用途公开(公告)号：US07956075B2
公开(公告)日：2011-06-07
申请号：US12001439
申请日：2007-12-11
申请人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
发明人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
IPC分类号： A61K31/425 , C07D277/28
CPC分类号： C07D277/28 , A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , C07D233/64 , C07D261/04 , C07D263/32 , C07D277/24 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06
摘要： The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl and Ω is —NR46R47 or —OR48, R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.
摘要翻译： 本发明涉及噻唑，恶唑，咪唑，异恶唑和其中Het为噻唑，恶唑，咪唑，异恶唑或异恶唑啉的通式（I）的异恶唑啉衍生物，n为0至6的整数，A特别选自各种任选取代的 芳基，B特别是氢，烷基或苯基，R 1和R 2特别独立地是氢，烷基或环烷基，和OHgr; 是-NR46R47或-OR48，R46和R47独特地是氢，烷基，环烷基或 - （CH2）k-COOR51，R51尤其是烷基或卤代烷基，R48特别是氢或烷基。 这些化合物具有有利的药理学性质，其允许其用于治疗学，特别是用于治疗神经变性疾病或疼痛。
-
公开(公告)号：US07659266B2
公开(公告)日：2010-02-09
申请号：US12090991
申请日：2006-10-18
IPC分类号： C07D279/20 , C07D417/12 , A61K31/5415
CPC分类号： C07D417/12 , C07D279/16 , C07D279/20
摘要： The invention concerns amidine derivatives of general formula (I) exhibiting an inhibitory activity of calpains and/or a trapping activity of reactive forms of oxygen.
摘要翻译： 本发明涉及显示钙激素抑制活性和/或氧反应形式捕获活性的通式（I）的脒衍生物。
-
公开(公告)号：US07192975B2
公开(公告)日：2007-03-20
申请号：US10517267
申请日：2003-07-24
IPC分类号： A61K31/4178 , C07D409/12
CPC分类号： C07D409/12 , C07D409/14
摘要： Compounds of the formula wherein the substituents are as defined in the specification which are useful for the treatment of pain.
摘要翻译： 下式的化合物其中取代基如说明书中所定义，其可用于治疗疼痛。
-
8.发明申请COMPOSITION CONTAINING AMIDINE DERIVATIVES OR CARBOXAMIDE DERIVATIVES AND STEROIDS, AS A MEDICAMENT 失效含有氨基衍生物或羧甲酰胺衍生物和甾体的组合物作为药物公开(公告)号：US20090149430A1
公开(公告)日：2009-06-11
申请号：US12282131
申请日：2007-03-06
IPC分类号： A61K31/5415 , A61K31/573 , A61P29/00 , A61P37/00 , A61P35/00 , A61P31/12 , A61K8/49
CPC分类号： A61K31/341 , A61K31/5415 , A61K31/573 , A61K31/58 , A61K31/585 , A61K2300/00
摘要： The present invention relates to a composition containing at least one amidine derivative or carboxamide derivative of general formula (I) or (A) in combination with at least one compound chosen from steroids, corticoids or corticosteroids, wherein said composition is suitable for the preparation of a medicament.
摘要翻译： 本发明涉及包含至少一种通式（I）或（A）的脒衍生物或羧酰胺衍生物与至少一种选自类固醇，皮质激素或皮质类固醇的化合物组合的组合物，其中所述组合物适用于制备 药物。
-
公开(公告)号：US20090018120A1
公开(公告)日：2009-01-15
申请号：US12090991
申请日：2006-10-18
IPC分类号： A61K31/5415 , C07D279/18 , A61P29/00 , A61P37/00 , A61P9/00 , A61P25/00 , A61P19/10 , A61P35/00 , A61P31/12
CPC分类号： C07D417/12 , C07D279/16 , C07D279/20
摘要： The invention concerns amidine derivatives of general formula (I) exhibiting an inhibitory activity of calpains and/or a trapping activity of reactive forms of oxygen.
摘要翻译： 本发明涉及显示钙激素抑制活性和/或氧反应形式捕获活性的通式（I）的脒衍生物。
-
10.发明申请公开(公告)号：US20080207709A1
公开(公告)日：2008-08-28
申请号：US11995092
申请日：2006-07-07
IPC分类号： A61K31/425 , A61P43/00
CPC分类号： A61K31/426 , A61K31/198 , A61K31/427 , C07D277/28
摘要： The invention relates to the use of derivatives of thiazoles having general formula (I) for the preparation of a medicament for the treatment or prevention of dyskinesias caused by a chemical treatment. The invention also relates to a combination of thiazole derivatives having general formula (I) and at least one compound selected from among neuroleptics or products that act on the dopaminergic system for the treatment or prevention of dyskinesias caused by a chemical treatment.
摘要翻译： 本发明涉及具有通式（I）的噻唑衍生物在制备用于治疗或预防由化学治疗引起的运动障碍的药物中的用途。 本发明还涉及具有通式（I）的噻唑衍生物和选自神经安定药或作用于多巴胺能系统的产品的至少一种化合物的组合，用于治疗或预防由化学治疗引起的运动障碍。
-
-
-
-
-
-
-
-
-
搜索结果
29 条记录 (耗时 0.049 秒)
