发明授权
US07312070B2 β-catenin oligonucleotide microchip and method for detecting β-catenin mutations employing same
有权
β-连环蛋白寡核苷酸微芯片和使用其检测β-连环蛋白突变的方法
- 专利标题： β-catenin oligonucleotide microchip and method for detecting β-catenin mutations employing same
- 专利标题（中）： β-连环蛋白寡核苷酸微芯片和使用其检测β-连环蛋白突变的方法
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申请号： US10659583申请日： 2003-09-09
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公开(公告)号： US07312070B2公开(公告)日： 2007-12-25
- 发明人: Jae-Gahb Park , Il-Jin Kim , Hio-Chung Kang , Jae-Hyun Park
- 申请人： Jae-Gahb Park , Il-Jin Kim , Hio-Chung Kang , Jae-Hyun Park
- 申请人地址： KR
- 专利权人： National Cancer Center
- 当前专利权人： National Cancer Center
- 当前专利权人地址： KR
- 代理机构： Anderson Kill & Olick, PC
- 优先权： KR10-2003-0000987 20030108
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12M1/38 ; C07H21/04
摘要：
The present invention relates to a β-catenin oligonucleotide microchip for detecting mutation in the mutational hot spot regions of β-catenin gene, a manufacturing process thereof and a method for detecting the β-catenin mutation employing same, wherein specific oligonucleotides are selectively designed to detect various missense mutations and in-frame deletion at the mutational hot spots of β-catenin gene. The β-catenin oligo chip of the present invention can be used in studies to detect β-catenin mutations and unravel the signal transduction mechanism and tumorigenesis related to β-catenin gene.