Invention Grant
- Patent Title: Inhibitors of cathepsin S
- Patent Title (中): 组织蛋白酶S抑制剂
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Application No.: US10922515Application Date: 2004-08-18
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Publication No.: US07314872B2Publication Date: 2008-01-01
- Inventor: Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
- Applicant: Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
- Applicant Address: BM Hamiltom
- Assignee: IRM LLC
- Current Assignee: IRM LLC
- Current Assignee Address: BM Hamiltom
- Agency: Genomics Institute of the Novartis Research Foundation
- Agent Emily Tongco Wu
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D295/10 ; A61K31/5377 ; A61K31/5375
Abstract:
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula I: wherein Q is morpholinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.
Public/Granted literature
- US20050113356A1 Inhibitors of cathepsin S Public/Granted day:2005-05-26
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