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公开(公告)号：US20150366856A1
公开(公告)日：2015-12-24
申请号：US14813397
申请日：2015-07-30
Applicant: David C. Tully , Vincent Paul Rucker , Phillip Alper , Daniel Mutnick , Donatella CHIANELLI
Inventor： David C. Tully , Vincent Paul Rucker , Phillip Alper , Daniel Mutnick , Donatella CHIANELLI
IPC: A61K31/46 , A61K31/497 , A61K31/506
CPC classification number: A61K31/46 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/706 , A61K45/06 , C07D451/06 , C07D471/04 , C07D487/04 , C07D519/00 , C07H17/00
Abstract: The present invention relates to compounds of Formula (I), a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesiod X receptors (FXR).
Abstract translation: 本发明涉及式（I）的化合物，其立体异构体，对映异构体，其药学上可接受的盐或氨基酸缀合物; 其中变量如本文所定义; 和它们的药物组合物，其可用作Farnesiod X受体（FXR）活性的调节剂。
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公开(公告)号：US09150568B2
公开(公告)日：2015-10-06
申请号：US13993138
申请日：2011-11-30
Applicant: David C. Tully , Paul Vincent Rucker , Phillip B. Alper , Daniel Mutnick , Donatella Chianelli
Inventor： David C. Tully , Paul Vincent Rucker , Phillip B. Alper , Daniel Mutnick , Donatella Chianelli
IPC: C07D451/06 , C07D519/00 , C07H17/00 , A61K45/06 , A61K31/46 , A61K31/506 , A61K31/497 , A61K31/501 , A61K31/4709 , A61K31/5025 , A61K31/706 , C07D471/04 , C07D487/04
CPC classification number: A61K31/46 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/706 , A61K45/06 , C07D451/06 , C07D471/04 , C07D487/04 , C07D519/00 , C07H17/00
Abstract: The present invention relates to compounds of Formula (I), a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesiod X receptors (FXR).
Abstract translation: 本发明涉及式（I）的化合物，其立体异构体，对映异构体，其药学上可接受的盐或氨基酸缀合物; 其中变量如本文所定义; 和它们的药物组合物，其可用作Farnesiod X受体（FXR）活性的调节剂。
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公开(公告)号：US20090137570A1
公开(公告)日：2009-05-28
申请号：US12361287
申请日：2009-01-28
Applicant: Hong LIU , Arnab K. CHATTERJEE , David C. TULLY , Phillip B. ALPER , Badry BURSULAYA , Jianhua GUO , David H. WOODMANSEE , Daniel MUTNICK , Donald S. KARANEWSKY , Yun HE
Inventor： Hong LIU , Arnab K. CHATTERJEE , David C. TULLY , Phillip B. ALPER , Badry BURSULAYA , Jianhua GUO , David H. WOODMANSEE , Daniel MUTNICK , Donald S. KARANEWSKY , Yun HE
IPC: A61K31/5377 , C07D413/12 , C07D295/145 , C07D413/14 , C07D279/12 , C07D241/04 , C07D417/12 , A61K31/454 , A61K31/404 , A61K31/495 , C07D403/12 , C07D401/12 , C07D209/08 , A61K31/541 , A61K31/54
CPC classification number: C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
Abstract translation: 本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。
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4.发明申请公开(公告)号：US20130261108A1
公开(公告)日：2013-10-03
申请号：US13993158
申请日：2011-11-30
Applicant: David C. Tully , Agnes Vidal , Daniel Mutnick , Phillip B. Alper
Inventor： David C. Tully , Agnes Vidal , Daniel Mutnick , Phillip B. Alper
IPC: A61K31/55 , A61K31/454 , A61K45/06 , C07D417/14
CPC classification number: A61K31/55 , A61K31/454 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/14
Abstract: The present invention relates to compounds of Formula (I), a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesiod X receptors (FXR).
Abstract translation: 本发明涉及式（I）的化合物，其立体异构体，对映异构体，其药学上可接受的盐或氨基酸缀合物; 其中变量如本文所定义; 和它们的药物组合物，其可用作Farnesiod X受体（FXR）活性的调节剂。
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公开(公告)号：US20120196844A1
公开(公告)日：2012-08-02
申请号：US13423041
申请日：2012-03-16
Applicant: Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
Inventor： Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
IPC: A61K31/496 , C07D401/14 , A61K31/497 , A61K31/501 , A61K31/551 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/00 , A61P9/10 , A61P3/08 , A61P3/00 , A61P19/02 , A61P19/10 , A61P9/12 , A61P9/04 , A61P27/02 , A61P27/12 , A61P13/12 , A61P7/02 , A61P7/00 , A61P15/10 , A61P17/00 , A61P19/04 , A61P1/04 , C12N5/02 , C07D401/12
CPC classification number: C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048
Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
Abstract translation: 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与GPR119活性相关的疾病或病症的方法。
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Patent Agency Ranking
公开(公告)号：US08153671B2
公开(公告)日：2012-04-10
申请号：US11995683
申请日：2006-07-14
Applicant: Phillip B. Alper , Thomas Marsilje , Arnab Chatterjee , Wenshuo Lu , Daniel Mutnick , Michael Roberts , Yun He
Inventor： Phillip B. Alper , Thomas Marsilje , Arnab Chatterjee , Wenshuo Lu , Daniel Mutnick , Michael Roberts , Yun He
IPC: A61K31/404 , C07D487/02
CPC classification number: C08J7/04 , C07D209/80 , C07D209/94 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D491/04 , C07D495/04 , C08J7/045 , C08J2369/00
Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
Abstract translation: 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TPO活性相关的疾病或病症的方法，特别是涉及血小板减少症的疾病或病症。
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公开(公告)号：US20110172244A1
公开(公告)日：2011-07-14
申请号：US12918804
申请日：2009-02-20
Applicant: Phillip B. Alper , Robert Epple , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin
Inventor： Phillip B. Alper , Robert Epple , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin
IPC: A61K31/496 , C07D401/06 , A61K31/454 , C07D405/06 , A61K31/4525 , C07D403/06 , C07D405/14 , C07D401/14 , C07D209/42 , A61K31/404 , C12N5/071 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/00 , A61P9/10 , A61P3/08 , A61P19/02 , A61P19/10 , A61P9/12 , A61P9/04 , A61P27/02 , A61P13/12 , A61P3/00 , A61P7/02 , A61P19/04 , A61P17/00 , A61P15/00
CPC classification number: C07D401/06 , C07D209/42 , C07D307/85 , C07D401/12 , C07D405/06 , C07D405/12
Abstract: The invention provides compounds, of Formula I: pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
Abstract translation: 本发明提供式I化合物：包含这些化合物的药物组合物和使用这些化合物治疗或预防与GPR119活性相关的疾病或病症的方法。
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公开(公告)号：US20130331349A1
公开(公告)日：2013-12-12
申请号：US13993138
申请日：2011-11-30
Applicant: David C. Tully , Paul Vincent Rucker , Phillip B. Alper , Daniel Mutnick , Donatella Chianelli
Inventor： David C. Tully , Paul Vincent Rucker , Phillip B. Alper , Daniel Mutnick , Donatella Chianelli
IPC: C07D451/06 , C07H17/00 , A61K45/06 , A61K31/46 , A61K31/706 , A61K31/497 , A61K31/501 , A61K31/4709 , A61K31/5025 , C07D519/00 , A61K31/506
CPC classification number: A61K31/46 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/706 , A61K45/06 , C07D451/06 , C07D471/04 , C07D487/04 , C07D519/00 , C07H17/00
Abstract: The present invention relates to compounds of Formula (I), a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesiod X receptors (FXR).
Abstract translation: 本发明涉及式（I）的化合物，其立体异构体，对映异构体，其药学上可接受的盐或氨基酸缀合物; 其中变量如本文所定义; 和它们的药物组合物，其可用作Farnesiod X受体（FXR）活性的调节剂。
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公开(公告)号：US20110245243A1
公开(公告)日：2011-10-06
申请号：US13161555
申请日：2011-06-16
Applicant: Hong LIU , David C. TULLY , Arnab CHATTERJEE , Phillip B. ALPER , David H. WOODMANSEE , Daniel MUTNICK
Inventor： Hong LIU , David C. TULLY , Arnab CHATTERJEE , Phillip B. ALPER , David H. WOODMANSEE , Daniel MUTNICK
IPC: A61K31/5377 , A61K31/5375 , A61K31/454 , A61K31/4245 , A61K31/423 , C07D413/12 , C07D265/30 , A61P43/00 , C07D417/12
CPC classification number: C07D263/56 , C07D211/66 , C07D273/02 , C07D277/64 , C07D295/185 , C07D307/30
Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.
Abstract translation: 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与组织蛋白酶S活性相关的疾病或病症的方法。
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公开(公告)号：US20110224185A1
公开(公告)日：2011-09-15
申请号：US13113988
申请日：2011-05-23
Applicant: Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
Inventor： Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
IPC: A61K31/397 , C07D405/14 , A61K31/506 , C07D401/14 , C07D401/12 , A61K31/4545 , A61K31/497 , A61K31/496 , A61K31/551 , C07D487/04 , A61K31/4985 , A61K31/501 , C07D413/14 , A61K31/5377 , A61P3/10 , A61P9/00 , A61P19/00 , A61P13/12 , A61P3/06 , A61P17/00 , C12N5/02
CPC classification number: C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048
Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
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