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发明授权
US07314928B2 Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences 失效
制备吗啉代核苷酸的方法及其用于核酸序列分析和标记的用途

Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences
摘要：
The invention relates to the use of morpholino-nucleosides of formula: in which R1 represents a nucleic base and R2 represents a group corresponding to one of the following formulae: —(CH2)n—NH2 —(CH2)n—SH —(CH2)n—COOH —(CH2)n—OH —(CH2)n—NH—R3 —(CH2)n—SR3 —(CH2)n—CO—R3 —(CH2)n—OR3 in which n is an interger ranging from 1 to 12 and R3 is a group derived from a label, from a protein, from an enzyme, from a fatty acid or from a peptide, as chain terminators in a process of DNA or RNA sequencing by the Sanger method, or for the labelling of DNA or RNA fragments.
摘要（中）：

本发明涉及下式的吗啉代核苷的用途：其中R 1表示核酸，R 2表示对应于下式之一的基团： ？in-line-formula description =“In-line Formulas”end =“lead”？> - （CH 2） n 2 - （CH 2） n -SH <？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line -formulae description =“In-line Formulas”end =“lead”？ - （CH 2） ）线性公式描述=“在线公式”end =“tail”？> <？in-line-formula description =“In-line Formulas”end = - （CH 2）n - -NH-R 3 - （CH 2） “in-line-formula description =”In-line Formulas“end =”tail“？> <？in-line-formula description =”In - （CH 2）n - （CH 2）n - （CH 2） - （CH 2） ＆lt; / SUB＆gt;＆lt; 3＆lt; 3＆lt; 3＆lt; =“在线公式”end =“tail”？>其中n是1至12的整数，R 3是从蛋白质衍生自标签的基团，来自酶 ，从脂肪酸或肽中作为链终止子，通过Sanger方法进行DNA或RNA测序，或用于标记DNA或RNA片段。

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