发明授权
- 专利标题: Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell
- 专利标题(中): 用于将药剂或遗传物质递送到细胞中的多功能载体
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申请号: US10137355申请日: 2002-05-03
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公开(公告)号: US07314956B2公开(公告)日: 2008-01-01
- 发明人: Frank Q. Li , Yong Liang Chu , Shuren Zhu , Jian-Tai Qiu , Wan-Ching Lai
- 申请人: Frank Q. Li , Yong Liang Chu , Shuren Zhu , Jian-Tai Qiu , Wan-Ching Lai
- 申请人地址: US MD Rockville
- 专利权人: Vaxim, Inc.
- 当前专利权人: Vaxim, Inc.
- 当前专利权人地址: US MD Rockville
- 主分类号: C07C233/02
- IPC分类号: C07C233/02 ; C07C233/04 ; C07C233/05 ; C07C233/07 ; C07C233/17 ; C07C233/31 ; A61K31/16
摘要:
The present invention provides a drug delivery vehicle that can improve the pharmacokinetics of pharmacological agents. The invention relates to a multifunctional carrier capable of delivering a carried material such as a pharmacological agent or genetic material to a recipient. The multifunctional carrier includes a multifunctional core and a plurality of adduct molecules bonded thereto. The molecular carrier has surface functional groups which can be associated with a carried material. The carried material can be associated with the molecular carrier through covalent interactions or ionic interactions. The polyvalent core can be ethylene-diamine tetraacetic acid (EDTA) or succinic acid. The invention also relates to methods for producing and using such molecules.
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