利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

155 条记录 (耗时 0.054 秒)

    Fatty acid derivatives for oral administration endowed with high palatability
    4.
    发明授权
    Fatty acid derivatives for oral administration endowed with high palatability 有权
    用于口服给药的脂肪酸衍生物具有高适口性

    公开(公告)号：US09255062B2

    公开(公告)日：2016-02-09

    申请号：US12988556

    申请日：2009-04-21

    申请人： Roberto Berni Canani ,  Antonio Calignano ,  Orazio Mazzoni ,  Orietta Mazzoni ,  Anna Coruzzo

    发明人： Roberto Berni Canani ,  Antonio Calignano ,  Orazio Mazzoni ,  Anna Coruzzo

    IPC分类号： A61K31/40 ,  A61K31/44 ,  A61K31/165 ,  C07D213/127 ,  C07D207/04 ,  C07C15/04 ,  C07C231/02 ,  C07C233/31 ,  C07C233/91

    CPC分类号： C07C231/02 ,  C07C233/31 ,  C07C233/91

    摘要： The invention relates to novel derivatives of short-chain fatty acids, in particular derivatives of butyric acid, useful for all the known clinical applications of the latter, which show physicochemical characteristics suitable for an easy oral administration, being devoid of the unpleasant organoleptic properties that characterize butyrate. The new compounds are amide derivatives which can be synthesized by reaction of the corresponding fatty acid halide with a naturally occurring amino acid, phenylalanine or a suitable derivative thereof, and which are in a poorly hygroscopic, easily weighable form, stable to acids and alkalis and able to release the acid at the small and large bowel level in a constant manner over time. They do not have disagreeable odors and are practically tasteless, thus allowing the manufacture of preparations for oral administration also suitable for the therapy of chronic diseases and in the pediatric field.

    摘要翻译： 本发明涉及短链脂肪酸的新衍生物，特别是丁酸的衍生物，其可用于后者的所有已知临床应用，其显示适合于容易口服给药的物理化学特性，没有令人不愉快的感官特性， 表征丁酸盐。 新化合物是酰胺衍生物，其可以通过相应的脂肪酰卤与天然存在的氨基酸，苯丙氨酸或其合适的衍生物的反应合成，并且它们的吸水性差，易于称重的形式，对酸和碱稳定，并且 能够随着时间的推移以恒定的方式释放小肠和大肠的酸。 它们没有不愉快的气味，几乎没有味道，因此允许口服制剂的制备也适用于治疗慢性疾病和儿科领域。