Invention Grant
US07321027B2 Small technetium-99m and rhenium labeled agents and methods for imaging tumors
失效
小锝-99m和铼标记的药剂和肿瘤成像方法
- Patent Title: Small technetium-99m and rhenium labeled agents and methods for imaging tumors
- Patent Title (中): 小锝-99m和铼标记的药剂和肿瘤成像方法
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Application No.: US10279214Application Date: 2002-10-23
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Publication No.: US07321027B2Publication Date: 2008-01-22
- Inventor: Ashfaq Mahmood , Matthias Friebe , Cristina Bolzati , Alun G. Jones , Alan Davison
- Applicant: Ashfaq Mahmood , Matthias Friebe , Cristina Bolzati , Alun G. Jones , Alan Davison
- Applicant Address: US MA Cambridge US MA Cambridge
- Assignee: President and Fellows of Harvard College,Massachusetts Institute of Technology
- Current Assignee: President and Fellows of Harvard College,Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge US MA Cambridge
- Agency: Edwards Angell Palmer & Dodge LLP
- Agent George W. Neuner; Mark D. Russett
- Main IPC: C07F13/00
- IPC: C07F13/00
Abstract:
The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tumors, e.g., carcinomas, melanomas and other tumors. In another embodiment, the invention relates to methods of imaging tumors using radiolabeled metal complexes. Preferred radiolabeled complexes for imaging tumors include technetium and rhenium complexes. The high tumor uptake and significant tumor/nontumor ratios of the technetium complexes of the invention indicate that such small technetium-99m-based molecular probes can be developed as in-vivo diagnostic agents for melanoma and its metastases. In yet another embodiment, the invention relates to methods of treatment of tumors using a radiolabeled metal complex as a radiopharmaceutical agent to treat the tumor.
Public/Granted literature
- US20040097735A1 Small technetium-99m and rhenium labeled agents and methods for imaging tumors Public/Granted day:2004-05-20
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