发明授权
- 专利标题: Compounds and processes for single-pot attachment of a label to nucleic acid
- 专利标题(中): 将标签单核连接到核酸的化合物和方法
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申请号: US11415021申请日: 2006-05-01
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公开(公告)号: US07326780B2公开(公告)日: 2008-02-05
- 发明人: Paul M. Slattum , Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker
- 申请人: Paul M. Slattum , Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker
- 申请人地址: US WI Madison
- 专利权人: Mirus Bio Corporation
- 当前专利权人: Mirus Bio Corporation
- 当前专利权人地址: US WI Madison
- 代理商 Kirk Ekena; Mark K. Johnson
- 主分类号: C07H21/00
- IPC分类号: C07H21/00 ; C07H21/02 ; C07H21/04 ; C12Q1/68 ; G01N33/53
摘要:
Compounds and methods are provided for a single-pot covalent attachment of a label to nucleic acids comprising forming a covalently attachable labeling reagent for alkylating the molecule. Then, combining the covalently attachable labeling reagent with a mixture containing the molecule, under conditions wherein the labeling reagent has reactivity with the molecule thereby forming a covalent bond.
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