Invention Grant
- Patent Title: Gossypol co-crystals and the use thereof
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Application No.: US11089096Application Date: 2005-03-24
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Publication No.: US07342046B2Publication Date: 2008-03-11
- Inventor: Shaomeng Wang , Jiangyong Chen
- Applicant: Shaomeng Wang , Jiangyong Chen
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones, S.C.
- Main IPC: A61K31/225
- IPC: A61K31/225 ; A61K31/11 ; A61K31/70

Abstract:
This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
Public/Granted literature
- US20050234135A1 Gossypol co-crystals and the use thereof Public/Granted day:2005-10-20
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