公开(公告)号：US20070293585A1

公开(公告)日：2007-12-20

申请号：US11818766

申请日：2007-06-15

申请人： Shaomeng Wang ,  Jiangyong Chen

发明人： Shaomeng Wang ,  Jiangyong Chen

IPC分类号： A61K31/11 ,  A61P31/00 ,  A61P31/04 ,  A61P33/00 ,  A61P35/00

CPC分类号： A61K31/11

摘要： This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.

摘要翻译： 本发明涉及包含（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体的组合物，其可用作 Bcl-2家族蛋白。 本发明还涉及（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体用于诱导细胞凋亡 细胞和致敏细胞诱导凋亡细胞死亡。

公开(公告)号：US20050234135A1

公开(公告)日：2005-10-20

申请号：US11089096

申请日：2005-03-24

申请人： Shaomeng Wang ,  Jiangyong Chen

发明人： Shaomeng Wang ,  Jiangyong Chen

IPC分类号： A61K31/11

CPC分类号： A61K31/11

摘要： This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.

摘要翻译： 本发明涉及包含（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体的组合物，其可用作 Bcl-2家族蛋白。 本发明还涉及（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体用于诱导细胞凋亡 细胞和致敏细胞诱导凋亡细胞死亡。

公开(公告)号：US07342046B2

公开(公告)日：2008-03-11

申请号：US11089096

申请日：2005-03-24

申请人： Shaomeng Wang ,  Jiangyong Chen

发明人： Shaomeng Wang ,  Jiangyong Chen

IPC分类号： A61K31/225 ,  A61K31/11 ,  A61K31/70

CPC分类号： A61K31/11

摘要： This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.

公开(公告)号：US07737174B2

公开(公告)日：2010-06-15

申请号：US11848089

申请日：2007-08-30

申请人： Shaomeng Wang ,  Dongguang Qin ,  Jiangyong Chen ,  Shanghai Yu

发明人： Shaomeng Wang ,  Dongguang Qin ,  Jiangyong Chen ,  Shanghai Yu

IPC分类号： A61K31/404 ,  C07D209/30 ,  C07D209/34

CPC分类号： C07D487/10 ,  C07D491/10

摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

摘要翻译： 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US07432300B2

公开(公告)日：2008-10-07

申请号：US11818766

申请日：2007-06-15

申请人： Shaomeng Wang ,  Jiangyong Chen

发明人： Shaomeng Wang ,  Jiangyong Chen

IPC分类号： A61K31/225 ,  A61K31/11 ,  A61K31/70

CPC分类号： A61K31/11

摘要： This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.

摘要翻译： 本发明涉及包含（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体的组合物，其可用作 Bcl-2家族蛋白。 本发明还涉及（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体用于诱导细胞凋亡 细胞和致敏细胞诱导凋亡细胞死亡。

公开(公告)号：US20080125430A1

公开(公告)日：2008-05-29

申请号：US11848089

申请日：2007-08-30

申请人： Shaomeng Wang ,  Dongguang Qin ,  Jiangyong Chen ,  Shanghai Yu

发明人： Shaomeng Wang ,  Dongguang Qin ,  Jiangyong Chen ,  Shanghai Yu

IPC分类号： A61K31/5377 ,  C07D209/96 ,  A61K31/407 ,  C07D265/30 ,  A61K31/445 ,  A61P35/00 ,  C07D211/06 ,  C07D241/04 ,  A61K31/497

CPC分类号： C07D487/10 ,  C07D491/10

摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

摘要翻译： 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。