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公开(公告)号：US07737174B2
公开(公告)日：2010-06-15
申请号：US11848089
申请日：2007-08-30
Applicant: Shaomeng Wang , Dongguang Qin , Jiangyong Chen , Shanghai Yu
Inventor： Shaomeng Wang , Dongguang Qin , Jiangyong Chen , Shanghai Yu
IPC: A61K31/404 , C07D209/30 , C07D209/34
CPC classification number: C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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公开(公告)号：US07342046B2
公开(公告)日：2008-03-11
申请号：US11089096
申请日：2005-03-24
Applicant: Shaomeng Wang , Jiangyong Chen
Inventor： Shaomeng Wang , Jiangyong Chen
IPC: A61K31/225 , A61K31/11 , A61K31/70
CPC classification number: A61K31/11
Abstract: This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
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公开(公告)号：US20070293585A1
公开(公告)日：2007-12-20
申请号：US11818766
申请日：2007-06-15
Applicant: Shaomeng Wang , Jiangyong Chen
Inventor： Shaomeng Wang , Jiangyong Chen
CPC classification number: A61K31/11
Abstract: This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
Abstract translation: 本发明涉及包含（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体的组合物，其可用作 Bcl-2家族蛋白。 本发明还涉及（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体用于诱导细胞凋亡 细胞和致敏细胞诱导凋亡细胞死亡。
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公开(公告)号：US20050234135A1
公开(公告)日：2005-10-20
申请号：US11089096
申请日：2005-03-24
Applicant: Shaomeng Wang , Jiangyong Chen
Inventor： Shaomeng Wang , Jiangyong Chen
IPC: A61K31/11
CPC classification number: A61K31/11
Abstract: This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
Abstract translation: 本发明涉及包含（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体的组合物，其可用作 Bcl-2家族蛋白。 本发明还涉及（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体用于诱导细胞凋亡 细胞和致敏细胞诱导凋亡细胞死亡。
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公开(公告)号：US07432300B2
公开(公告)日：2008-10-07
申请号：US11818766
申请日：2007-06-15
Applicant: Shaomeng Wang , Jiangyong Chen
Inventor： Shaomeng Wang , Jiangyong Chen
IPC: A61K31/225 , A61K31/11 , A61K31/70
CPC classification number: A61K31/11
Abstract: This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
Abstract translation: 本发明涉及包含（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体的组合物，其可用作 Bcl-2家族蛋白。 本发明还涉及（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体用于诱导细胞凋亡 细胞和致敏细胞诱导凋亡细胞死亡。
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Patent Agency Ranking
公开(公告)号：US20080125430A1
公开(公告)日：2008-05-29
申请号：US11848089
申请日：2007-08-30
Applicant: Shaomeng Wang , Dongguang Qin , Jiangyong Chen , Shanghai Yu
Inventor： Shaomeng Wang , Dongguang Qin , Jiangyong Chen , Shanghai Yu
IPC: A61K31/5377 , C07D209/96 , A61K31/407 , C07D265/30 , A61K31/445 , A61P35/00 , C07D211/06 , C07D241/04 , A61K31/497
CPC classification number: C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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7.发明授权Process for the preparation of small molecule inhibitors of MDM2 and intermediates used therein 失效制备MDM2的小分子抑制剂的方法及其中使用的中间体公开(公告)号：US08742121B2
公开(公告)日：2014-06-03
申请号：US13614751
申请日：2012-09-13
Applicant: Shaomeng Wang , Ke Ding , Guoping Wang
Inventor： Shaomeng Wang , Ke Ding , Guoping Wang
IPC: C07D401/02 , C07D487/10 , C07D209/04
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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公开(公告)号：US08664212B2
公开(公告)日：2014-03-04
申请号：US13557804
申请日：2012-07-25
Applicant: Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
Inventor： Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
IPC: A61K31/33 , C07D245/04 , C07D487/02
CPC classification number: G01N33/5011 , C07D487/04
Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的重氮二环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US20120309961A1
公开(公告)日：2012-12-06
申请号：US13557804
申请日：2012-07-25
Applicant: Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
Inventor： Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
IPC: C07D487/04
CPC classification number: G01N33/5011 , C07D487/04
Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的重氮二环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US20120289494A1
公开(公告)日：2012-11-15
申请号：US13469928
申请日：2012-05-11
Applicant: Shaomeng Wang , Wei Sun , Angelo Aguilar , Carlos Garcia-Echeverria
Inventor： Shaomeng Wang , Wei Sun , Angelo Aguilar , Carlos Garcia-Echeverria
IPC: A61K31/407 , A61K31/5377 , A61P35/00 , A61K31/438 , A61K31/41 , C07D487/10 , C07D471/20
CPC classification number: C07D487/10
Abstract: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
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