发明授权
- 专利标题： Human antihuman MCP-1 antibody and antibody fragment thereof
- 专利标题（中）： 人抗人MCP-1抗体及其抗体片段
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申请号： US10527823申请日： 2003-09-10
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公开(公告)号： US07342106B2公开(公告)日： 2008-03-11
- 发明人: Kazuhisa Sugimura , Toshihiro Nakashima , Tsukasa Nishihara
- 申请人： Kazuhisa Sugimura , Toshihiro Nakashima , Tsukasa Nishihara
- 申请人地址： JP Kumamato-Ken
- 专利权人： Judicial Foundation The Chemo-Sero-Therapeutic Research Institute
- 当前专利权人： Judicial Foundation The Chemo-Sero-Therapeutic Research Institute
- 当前专利权人地址： JP Kumamato-Ken
- 代理机构： Browdy and Neimark, PLLC
- 优先权： JP2002-267184 20020912
- 国际申请： PCT/JP03/11560 WO 20030910
- 国际公布： WO2004/024921 WO 20040325
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07K16/00
摘要：
A substance effective for treating immunopathy where MCP-1 is involved is provided. scFv having a high affinity to human MCP-1 was obtained using phage antibody technique. Based on information of VH chain and VL chain obtained from said scFv, a human anti-human MCP-1 antibody and a human anti-human MCP-1 antibody fragment are obtained. Said antibody and antibody fragment are expected to be useful as a medicament for treating inflammation and immunopathy caused by MCP-1.
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