-
公开(公告)号：US07342106B2
公开(公告)日：2008-03-11
申请号：US10527823
申请日：2003-09-10
CPC分类号： C07K16/24 , C07K2317/21 , C07K2317/622 , C07K2317/64 , C07K2317/76
摘要： A substance effective for treating immunopathy where MCP-1 is involved is provided. scFv having a high affinity to human MCP-1 was obtained using phage antibody technique. Based on information of VH chain and VL chain obtained from said scFv, a human anti-human MCP-1 antibody and a human anti-human MCP-1 antibody fragment are obtained. Said antibody and antibody fragment are expected to be useful as a medicament for treating inflammation and immunopathy caused by MCP-1.
摘要翻译： 提供了有效治疗涉及MCP-1的免疫病的物质。 使用噬菌体抗体技术获得对人MCP-1具有高亲和力的scFv。 基于从所述scFv获得的VH链和VL链的信息，获得人抗人MCP-1抗体和人抗人MCP-1抗体片段。 预期所述抗体和抗体片段可用作治疗由MCP-1引起的炎症和免疫病症的药物。
-
2.发明授权Human anti-human interleukin-18 antibody, fragment thereof and method for using same 失效人抗人白介素-18抗体及其片段及其使用方法公开(公告)号：US07491803B2
公开(公告)日：2009-02-17
申请号：US10555074
申请日：2004-04-30
CPC分类号： C07K16/244 , C07K2317/21 , C07K2317/565
摘要： A human-derived human anti-human IL-18 antibody of the present invention is an antibody against human IL-18, the antibody including: an H-chain complementarity determining region consisting of (a) a polypeptide consisting of amino-acid sequences represented by SEQ ID NOS: 4 to 6, or (b) a polypeptide which is a mutant of the polypeptide (a) and which serves as the H-chain complementarity determining region; and an L-chain complementarity determining region against human interleukin-18 consisting of (c) a polypeptide consisting of amino-acid sequences represented by SEQ ID NOS: 10 to 12, or (d) a polypeptide which is a mutant of the polypeptide (c) and which serves as the L-chain complementarity determining region. This makes it possible to provide a human anti-human IL-18 antibody and a method for using the antibody.
摘要翻译： 本发明的人衍生的人抗人IL-18抗体是针对人IL-18的抗体，所述抗体包括：H链互补决定区，其由（a）由氨基酸序列表示的多肽组成 通过SEQ ID NO：4至6，或（b）多肽（a）的突变体并用作H链互补决定区的多肽; 和由（c）由SEQ ID NO：10至12表示的氨基酸序列组成的多肽的人白介素-18组成的L链互补决定区，或（d）多肽突变体的多肽（ c）并且其用作L链互补决定区。 这使得可以提供人抗人IL-18抗体和使用该抗体的方法。
-
公开(公告)号：US07482436B2
公开(公告)日：2009-01-27
申请号：US10526072
申请日：2003-08-28
IPC分类号： C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/622 , C07K2317/73
摘要： A substance effective for treating immunopathy where interleukin 6 (IL-6) is involved is provided. A human anti-human IL-6 antibody and a human anti-human IL-6 antibody fragment having a high affinity to human IL-6 were obtained using phage antibody technique. The antibody and antibody fragment are expected to be useful as a medicament for treating inflammation and immunopathy caused by IL-6.
摘要翻译： 提供了有效治疗涉及白介素6（IL-6）的免疫病的物质。 使用噬菌体抗体技术获得对人IL-6具有高亲和力的人抗人IL-6抗体和人抗人IL-6抗体片段。 预期抗体和抗体片段可用作治疗由IL-6引起的炎症和免疫病症的药物。
-
公开(公告)号：US20050170451A1
公开(公告)日：2005-08-04
申请号：US10484206
申请日：2002-07-18
CPC分类号： C07K16/283 , A61K2039/505 , C07K2317/21 , C07K2317/622 , Y10S424/805
摘要： An antibody or an antibody fragment is provided that is efficacious for treating allergic diseases in which IgE is involved. A human antibody and a fragment thereof to a receptor (FcεRI) having high affinity to Fc portion of IgE was obtained using phage antibody display technique. The human anti-IgE receptor antibody and a fragment thereof of the invention has an activity to inhibit the binding between IgE and IgE receptor and hence is expected to be useful as a medicament for treating allergic diseases caused by the binding between IgE and IgE receptor.
摘要翻译： 提供抗体或抗体片段，其对于治疗涉及IgE的过敏性疾病是有效的。 使用噬菌体抗体展示技术，获得对IgE的Fc部分具有高亲和力的受体（FcepsilonRI）的人抗体及其片段。 本发明的人抗IgE受体抗体及其片段具有抑制IgE和IgE受体之间结合的活性，因此预期可用作治疗由IgE和IgE受体结合引起的过敏性疾病的药物。
-
5.发明授权公开(公告)号：US08222002B2
公开(公告)日：2012-07-17
申请号：US12792064
申请日：2010-06-02
CPC分类号： G01N33/6896 , A61K31/7088 , A61K48/00 , C07K16/18 , C07K2317/21 , C07K2317/622 , G01N2333/4709 , G01N2800/2821
摘要： A human anti-amyloid β peptide (hereinafter referred to as “Aβ”) antibody that binds to Aβ to thereby inhibit aggregation of Aβ molecules, and a fragment of said antibody are provided. The antibody and a fragment thereof according to the present invention, comprising a variable region of a human-derived anti-Aβ antibody, strongly reacts with Aβ to thereby inhibit its aggregation and hence may be used as a medicament for the prophylaxis and treatment of Alzheimer dementia.
摘要翻译： 人类抗淀粉样蛋白 与A＆bgr结合的肽（以下称为“A＆bgr”）抗体; 从而抑制A＆bgr的聚集; 分子和所述抗体的片段。 根据本发明的抗体及其片段，其包含人衍生的抗A＆Bgr的可变区; 抗体与A＆bgr强烈反应; 从而抑制其聚集，因此可以用作预防和治疗阿尔茨海默氏痴呆的药物。
-
公开(公告)号：US20060240012A1
公开(公告)日：2006-10-26
申请号：US10526072
申请日：2003-08-28
CPC分类号： C07K16/248 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/622 , C07K2317/73
摘要： A substance effective for treating immunopathy where interleukin 6 (IL-6) is involved is provided. A human anti-human IL-6 antibody and a human anti-human IL-6 antibody fragment having a high affinity to human IL-6 were obtained using phage antibody technique. Said antibody and antibody fragment are expected to be useful as a medicament for treating inflammation and immunopathy caused by IL-6.
摘要翻译： 提供了有效治疗涉及白介素6（IL-6）的免疫病的物质。 使用噬菌体抗体技术获得对人IL-6具有高亲和力的人抗人IL-6抗体和人抗人IL-6抗体片段。 预期所述抗体和抗体片段可用作治疗由IL-6引起的炎症和免疫疾病的药物。
-
公开(公告)号：US07384633B2
公开(公告)日：2008-06-10
申请号：US10484206
申请日：2002-07-18
IPC分类号： A61K39/395
CPC分类号： C07K16/283 , A61K2039/505 , C07K2317/21 , C07K2317/622 , Y10S424/805
摘要： An antibody or an antibody fragment is provided that is efficacious for treating allergic diseases in which IgE is involved. A human antibody and a fragment thereof to a receptor (FcεRI) having high affinity to Fc portion of IgE was obtained using phage antibody display technique. The human anti-IgE receptor antibody and a fragment thereof of the invention has an activity to inhibit the binding between IgE and IgE receptor and hence is expected to be useful as a medicament for treating allergic diseases caused by the binding between IgE and IgE receptor.
摘要翻译： 提供抗体或抗体片段，其对于治疗涉及IgE的过敏性疾病是有效的。 使用噬菌体抗体展示技术，获得对IgE的Fc部分具有高亲和力的受体（FcepsilonRI）的人抗体及其片段。 本发明的人抗IgE受体抗体及其片段具有抑制IgE和IgE受体之间结合的活性，因此预期可用作治疗由IgE和IgE受体结合引起的过敏性疾病的药物。
-
8.发明申请公开(公告)号：US20080131422A1
公开(公告)日：2008-06-05
申请号：US11579072
申请日：2005-04-21
IPC分类号： A61K39/00 , C07K16/00 , C07H21/04 , C12N15/00 , A61P43/00 , C12N5/00 , C12P21/04 , G01N33/53
CPC分类号： G01N33/6896 , A61K31/7088 , A61K48/00 , C07K16/18 , C07K2317/21 , C07K2317/622 , G01N2333/4709 , G01N2800/2821
摘要： A human anti-amyloid β peptide (hereinafter referred to as “Aβ”) antibody that binds to Aβ to thereby inhibit aggregation of Aβ molecules, and a fragment of said antibody are provided. The antibody and a fragment thereof according to the present invention, comprising a variable region of a human-derived anti-Aβ antibody, strongly reacts with Aβ to thereby inhibit its aggregation and hence may be used as a medicament for the prophylaxis and treatment of Alzheimer dementia.
摘要翻译： 提供了与Abeta结合从而抑制Abeta分子聚集的人抗淀粉样蛋白β肽（以下称为“Abeta”）抗体和所述抗体的片段。 包含人源抗Abeta抗体的可变区的本发明的抗体及其片段与Abeta强烈反应从而抑制其聚集，因此可用作预防和治疗阿尔茨海默病的药物 痴呆。
-
公开(公告)号：US07763249B2
公开(公告)日：2010-07-27
申请号：US11579072
申请日：2005-04-21
IPC分类号： A61K39/395 , C07K16/18 , C12P21/08
CPC分类号： G01N33/6896 , A61K31/7088 , A61K48/00 , C07K16/18 , C07K2317/21 , C07K2317/622 , G01N2333/4709 , G01N2800/2821
摘要： A human anti-amyloid β peptide (hereinafter referred to as “Aβ”) antibody that binds to Aβ to thereby inhibit aggregation of Aβ molecules, and a fragment of said antibody are provided. The antibody and a fragment thereof according to the present invention, comprising a variable region of a human-derived anti-Aβ antibody, strongly reacts with Aβ to thereby inhibit its aggregation and hence may be used as a medicament for the prophylaxis and treatment of Alzheimer dementia.
摘要翻译： 人类抗淀粉样蛋白 与A＆bgr结合的肽（以下称为“A＆bgr”）抗体; 从而抑制A＆bgr的聚集; 分子和所述抗体的片段。 根据本发明的抗体及其片段，其包含人衍生的抗A＆Bgr的可变区; 抗体与A＆bgr强烈反应; 从而抑制其聚集，因此可以用作预防和治疗阿尔茨海默氏痴呆的药物。
-
10.发明申请Human antihuman interleukin-18 antibody, fragment thereof and method for using same 失效人抗人白细胞介素-18抗体及其片段及其使用方法公开(公告)号：US20060292145A1
公开(公告)日：2006-12-28
申请号：US10555074
申请日：2004-04-30
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , C07K2317/21 , C07K2317/565
摘要： A human-derived human anti-human IL-18 antibody of the present invention is an antibody against human IL-18, the antibody including: an H-chain complementarity determining region consisting of (a) a polypeptide consisting of amino-acid sequences represented by SEQ ID NOS: 4 to 6, or (b) a polypeptide which is a mutant of the polypeptide (a) and which serves as the H-chain complementarity determining region; and an L-chain complementarity determining region against human interleukin-18 consisting of (c) a polypeptide consisting of amino-acid sequences represented by SEQ ID NOS: 10 to 12, or (d) a polypeptide which is a mutant of the polypeptide (c) and which serves as the L-chain complementarity determining region. This makes it possible to provide a human anti-human IL-18 antibody and a method for using the antibody.
摘要翻译： 本发明的人衍生的人抗人IL-18抗体是针对人IL-18的抗体，所述抗体包括：H链互补决定区，其由（a）由氨基酸序列表示的多肽组成 通过SEQ ID NO：4至6，或（b）多肽（a）的突变体并用作H链互补决定区的多肽; 和由（c）由SEQ ID NO：10至12表示的氨基酸序列组成的多肽的人白介素-18组成的L链互补决定区，或（d）多肽突变体的多肽（ c）并且其用作L链互补决定区。 这使得可以提供人抗人IL-18抗体和使用该抗体的方法。
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.017 秒)
