发明授权
- 专利标题： TNF-α production inhibitors
- 专利标题（中）： TNF-α产生抑制剂
-
申请号： US11472603申请日： 2006-06-22
-
公开(公告)号： US07345064B2公开(公告)日： 2008-03-18
- 发明人: Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
- 申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
- 申请人地址： JP Osaka
- 专利权人： Santen Pharmaceutical Co., Ltd.
- 当前专利权人： Santen Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Osaka
- 代理机构： Frishauf, Holtz, Goodman & Chick, P.C.
- 优先权： JP2000-162945 20000531
- 主分类号： C07D211/80
- IPC分类号： C07D211/80 ; A61K31/44
摘要：
A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein A is —(NR4)—, —(CR5R6)— or —O—, B is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and X is oxygen or sulfer respectively.
公开/授权文献
- US20060241155A1 TNF-alpha production inhibitors 公开/授权日：2006-10-26
信息查询
