发明授权
US07348003B2 Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
有权
使用免疫特异性结合TRAIL受体的抗体治疗癌症的方法
- 专利标题： Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
- 专利标题（中）： 使用免疫特异性结合TRAIL受体的抗体治疗癌症的方法
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申请号： US10986047申请日： 2004-11-12
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公开(公告)号： US07348003B2公开(公告)日： 2008-03-25
- 发明人: Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
- 申请人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
- 申请人地址： US MD Rockville
- 专利权人： Human Genome Sciences, Inc.
- 当前专利权人： Human Genome Sciences, Inc.
- 当前专利权人地址： US MD Rockville
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/53 ; C12P21/04 ; C12P21/08 ; C07K16/00 ; C07H21/04
摘要：
The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.