Invention Grant
US07365068B2 Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
失效
取代的芳基酰基硫脲和相关化合物; 病毒复制抑制剂
- Patent Title: Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
- Patent Title (中): 取代的芳基酰基硫脲和相关化合物; 病毒复制抑制剂
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Application No.: US11131013Application Date: 2005-05-17
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Publication No.: US07365068B2Publication Date: 2008-04-29
- Inventor: Avinash Phadke , Dawei Chen , Milind Deshpande , Andrew Thurkauf , Xiangzhu Wang , Yiping Shen , Cuixian Liu , Jesse Quinn , Junko Ohkanda , Shouming Li
- Applicant: Avinash Phadke , Dawei Chen , Milind Deshpande , Andrew Thurkauf , Xiangzhu Wang , Yiping Shen , Cuixian Liu , Jesse Quinn , Junko Ohkanda , Shouming Li
- Applicant Address: US CT New Haven
- Assignee: Achillion Pharmaceuticals, Inc.
- Current Assignee: Achillion Pharmaceuticals, Inc.
- Current Assignee Address: US CT New Haven
- Agency: Cantor Colburn LLP
- Main IPC: A61K31/496
- IPC: A61K31/496 ; A61K31/444 ; A61K31/5377 ; C07D211/78 ; C07D401/02 ; C07D401/06 ; C07D413/02 ; C07D413/06

Abstract:
The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease.Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.
Public/Granted literature
- US20060025416A1 Substituted aryl acylthioureas and related compounds; inhibitors of viral replication Public/Granted day:2006-02-02
Information query
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