Invention Grant
US07381402B2 Stable pharmaceutical solution formulations for pressurized metered dose inhalers
失效
用于加压计量剂量吸入器的稳定的药物溶液制剂
- Patent Title: Stable pharmaceutical solution formulations for pressurized metered dose inhalers
- Patent Title (中): 用于加压计量剂量吸入器的稳定的药物溶液制剂
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Application No.: US11065569Application Date: 2005-02-25
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Publication No.: US07381402B2Publication Date: 2008-06-03
- Inventor: David Lewis , David Ganderton , Brian Meakin , Maurizio Delcanale , Fausto Pivetti
- Applicant: David Lewis , David Ganderton , Brian Meakin , Maurizio Delcanale , Fausto Pivetti
- Applicant Address: IT Parma
- Assignee: Chiesi Farmaceutici S.p.A.
- Current Assignee: Chiesi Farmaceutici S.p.A.
- Current Assignee Address: IT Parma
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- Main IPC: A61K9/12
- IPC: A61K9/12 ; A61K9/08 ; A61K31/47 ; A61K31/4704 ; A61M11/00 ; A61M11/04 ; A61M15/00 ; A61M15/06

Abstract:
Aerosol solution formulations for use in an aerosol inhaler which comprise 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]-ethyl]-2(1H)-quinolinone or a salt thereof, in particular the hydrochloride salt (TA 2005), as an active ingredient, a propellant containing a hydrofluoroalkane, and a cosolvent, stabilized by addition of a specific small amount of a high concentrated phosphoric acid exhibit improved shelf life. The formulation may be optionally contained in a can having part or all of its internal metallic surfaces lined with an inert organic coating.
Public/Granted literature
- US20050220718A1 Stable pharmaceutical solution formulations for pressurized metered dose inhalers Public/Granted day:2005-10-06
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