发明授权
US07381805B2 Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF
失效
包含聚乙二醇化G-CSF的位置PEG异构体的混合物的组合物
- 专利标题： Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF
- 专利标题（中）： 包含聚乙二醇化G-CSF的位置PEG异构体的混合物的组合物
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申请号： US11420546申请日： 2006-05-26
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公开(公告)号： US07381805B2公开(公告)日： 2008-06-03
- 发明人: Carsten Germansen , Bobby Soni , Grethe Rasmussen
- 申请人： Carsten Germansen , Bobby Soni , Grethe Rasmussen
- 申请人地址： KY Grand Cayman
- 专利权人： Maxygen Holdings, Ltd.
- 当前专利权人： Maxygen Holdings, Ltd.
- 当前专利权人地址： KY Grand Cayman
- 代理机构： Maxygen, Inc.
- 代理商 Joanne R Petithory; Norman J Kruse
- 主分类号： C07K14/53
- IPC分类号： C07K14/53 ; A61K47/36 ; A61K38/24
摘要：
A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.
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