利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.018 秒)

    Compositions comprising positional isomers of PEGylated G-CSF
    1.
    发明授权
    Compositions comprising positional isomers of PEGylated G-CSF 失效
    包含聚乙二醇化G-CSF的位置异构体的组合物

    公开(公告)号：US07655766B2

    公开(公告)日：2010-02-02

    申请号：US11742445

    申请日：2007-04-30

    申请人： Carsten Germansen ,  Bobby Soni ,  Grethe Rasmussen

    发明人： Carsten Germansen ,  Bobby Soni ,  Grethe Rasmussen

    IPC分类号： C07K14/53 ,  A61K47/36 ,  A61K38/24

    CPC分类号： C07K14/535 ,  A61K38/193 ,  A61K47/60 ,  C12P21/02

    摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.

    摘要翻译： 增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法， 包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。

    PEGYLATED G-CSF POLYPEPTIDES AND METHODS OF PRODUCING SAME
    3.
    发明申请
    PEGYLATED G-CSF POLYPEPTIDES AND METHODS OF PRODUCING SAME 失效
    聚乙二醇化G-CSF多肽及其生产方法

    公开(公告)号：US20080090764A1

    公开(公告)日：2008-04-17

    申请号：US11742445

    申请日：2007-04-30

    申请人： Carsten GERMANSEN ,  Bobby SONI ,  Grethe RASMUSSEN

    发明人： Carsten GERMANSEN ,  Bobby SONI ,  Grethe RASMUSSEN

    IPC分类号： A61K38/19 ,  C07K14/53 ,  C12N15/09

    CPC分类号： C07K14/535 ,  A61K38/193 ,  A61K47/60 ,  C12P21/02

    摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.

    摘要翻译： 增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法， 包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。

    Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF
    4.
    发明授权
    Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF 失效
    包含聚乙二醇化G-CSF的位置PEG异构体的混合物的组合物

    公开(公告)号：US07381805B2

    公开(公告)日：2008-06-03

    申请号：US11420546

    申请日：2006-05-26

    申请人： Carsten Germansen ,  Bobby Soni ,  Grethe Rasmussen

    发明人： Carsten Germansen ,  Bobby Soni ,  Grethe Rasmussen

    IPC分类号： C07K14/53 ,  A61K47/36 ,  A61K38/24

    CPC分类号： C07K14/535 ,  A61K38/193 ,  A61K47/60 ,  C12P21/02

    摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.

    摘要翻译： 增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法， 包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。

    Method for recognition and reduction of blood speckle in blood vessel imaging system
    6.
    发明授权
    Method for recognition and reduction of blood speckle in blood vessel imaging system 失效
    血管成像系统中血斑识别和减少的方法

    公开(公告)号：US5363850A

    公开(公告)日：1994-11-15

    申请号：US187584

    申请日：1994-01-26

    申请人： Bobby Soni ,  Richard Didday ,  Kean Hurley

    发明人： Bobby Soni ,  Richard Didday ,  Kean Hurley

    IPC分类号： A61B8/06 ,  G01S7/52 ,  A61B8/00

    CPC分类号： A61B8/06 ,  A61B8/12 ,  G01S7/52036 ,  Y10S128/916

    摘要： In an ultrasound imaging system, ultrasound echoes representing vessel walls are distinguished from ultrasound echoes from blood by using a classifier which employs the mean and variance of the raw data of gray intensities as acquired directly from an ultrasound scanner detector. In a specific embodiment, the statistical parameters of mean and variance are determined in the course of real-time processing and prior to attempted classification and then are used as parameters representing the true image as acquired.

    摘要翻译： 在超声成像系统中，通过使用分类器来区分代表血管壁的超声回波，其使用从超声波扫描仪检测器直接获取的灰度强度的原始数据的平均值和方差。 在具体实施例中，在实时处理和尝试分类之前确定平均值和方差的统计参数，然后用作表示所获取的真实图像的参数。

    Method for recognition and reduction of blood speckle in blood vessel imaging system
    7.
    发明授权
    Method for recognition and reduction of blood speckle in blood vessel imaging system 失效
    血管成像系统中血斑识别和减少的方法

    公开(公告)号：US5520185A

    公开(公告)日：1996-05-28

    申请号：US340178

    申请日：1994-11-15

    申请人： Bobby Soni ,  Richard Didday ,  Kean Hurley

    发明人： Bobby Soni ,  Richard Didday ,  Kean Hurley

    IPC分类号： A61B8/06 ,  G01S7/52 ,  A61B8/00

    CPC分类号： A61B8/06 ,  A61B8/12 ,  G01S7/52036 ,  Y10S128/916

    摘要： In an ultrasound imaging system, ultrasound echoes representing vessel walls are distinguished from ultrasound echoes from blood by using a classifier which employs the mean and variance of the raw data of gray intensities as acquired directly from an ultrasound scanner detector. In a specific embodiment, the statistical parameters of mean and variance are determined in the course of real-time processing and prior to attempted classification and then are used as parameters representing the true image as acquired.

    摘要翻译： 在超声成像系统中，通过使用分类器来区分代表血管壁的超声回波，其使用从超声波扫描仪检测器直接获取的灰度强度的原始数据的平均值和方差。 在具体实施例中，在实时处理和尝试分类之前确定平均值和方差的统计参数，然后用作表示所获取的真实图像的参数。

    PEGYLATED G-CSF POLYPEPTIDES AND METHODS OF PRODUCING SAME
    9.
    发明申请
    PEGYLATED G-CSF POLYPEPTIDES AND METHODS OF PRODUCING SAME 审中-公开
    聚乙二醇化G-CSF多肽及其生产方法

    公开(公告)号：US20070014763A1

    公开(公告)日：2007-01-18

    申请号：US11532818

    申请日：2006-09-18

    申请人： Carsten GERMANSEN ,  Bobby SONI ,  Grethe RASMUSSEN

    发明人： Carsten GERMANSEN ,  Bobby SONI ,  Grethe RASMUSSEN

    IPC分类号： A61K38/19 ,  C07K14/535

    CPC分类号： C07K14/535 ,  A61K38/193 ,  A61K47/60 ,  C12P21/02

    摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.

    摘要翻译： 增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法， 包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。