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    Compositions comprising positional isomers of PEGylated G-CSF
    1.
    发明授权
    Compositions comprising positional isomers of PEGylated G-CSF 失效
    包含聚乙二醇化G-CSF的位置异构体的组合物

    公开(公告)号：US07655766B2

    公开(公告)日：2010-02-02

    申请号：US11742445

    申请日：2007-04-30

    申请人： Carsten Germansen ,  Bobby Soni ,  Grethe Rasmussen

    发明人： Carsten Germansen ,  Bobby Soni ,  Grethe Rasmussen

    IPC分类号： C07K14/53 ,  A61K47/36 ,  A61K38/24

    CPC分类号： C07K14/535 ,  A61K38/193 ,  A61K47/60 ,  C12P21/02

    摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.

    摘要翻译： 增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法， 包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。

    PEGYLATED G-CSF POLYPEPTIDES AND METHODS OF PRODUCING SAME
    2.
    发明申请
    PEGYLATED G-CSF POLYPEPTIDES AND METHODS OF PRODUCING SAME 失效
    聚乙二醇化G-CSF多肽及其生产方法

    公开(公告)号：US20080090764A1

    公开(公告)日：2008-04-17

    申请号：US11742445

    申请日：2007-04-30

    申请人： Carsten GERMANSEN ,  Bobby SONI ,  Grethe RASMUSSEN

    发明人： Carsten GERMANSEN ,  Bobby SONI ,  Grethe RASMUSSEN

    IPC分类号： A61K38/19 ,  C07K14/53 ,  C12N15/09

    CPC分类号： C07K14/535 ,  A61K38/193 ,  A61K47/60 ,  C12P21/02

    摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.

    摘要翻译： 增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法， 包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。

    Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF
    3.
    发明授权
    Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF 失效
    包含聚乙二醇化G-CSF的位置PEG异构体的混合物的组合物

    公开(公告)号：US07381805B2

    公开(公告)日：2008-06-03

    申请号：US11420546

    申请日：2006-05-26

    申请人： Carsten Germansen ,  Bobby Soni ,  Grethe Rasmussen

    发明人： Carsten Germansen ,  Bobby Soni ,  Grethe Rasmussen

    IPC分类号： C07K14/53 ,  A61K47/36 ,  A61K38/24

    CPC分类号： C07K14/535 ,  A61K38/193 ,  A61K47/60 ,  C12P21/02

    摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.

    摘要翻译： 增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法， 包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。

    PEGYLATED G-CSF POLYPEPTIDES AND METHODS OF PRODUCING SAME
    6.
    发明申请
    PEGYLATED G-CSF POLYPEPTIDES AND METHODS OF PRODUCING SAME 审中-公开
    聚乙二醇化G-CSF多肽及其生产方法

    公开(公告)号：US20070014763A1

    公开(公告)日：2007-01-18

    申请号：US11532818

    申请日：2006-09-18

    申请人： Carsten GERMANSEN ,  Bobby SONI ,  Grethe RASMUSSEN

    发明人： Carsten GERMANSEN ,  Bobby SONI ,  Grethe RASMUSSEN

    IPC分类号： A61K38/19 ,  C07K14/535

    CPC分类号： C07K14/535 ,  A61K38/193 ,  A61K47/60 ,  C12P21/02

    摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.

    摘要翻译： 增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法， 包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。