发明授权
US07384788B2 Regulator/promoter for tunable gene expression and metabolite sensing
失效
用于可调基因表达和代谢物检测的调节剂/启动子
- 专利标题： Regulator/promoter for tunable gene expression and metabolite sensing
- 专利标题（中）： 用于可调基因表达和代谢物检测的调节剂/启动子
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申请号： US11165160申请日： 2005-06-23
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公开(公告)号： US07384788B2公开(公告)日： 2008-06-10
- 发明人: Tina K. Van Dyk
- 申请人： Tina K. Van Dyk
- 申请人地址： US DE Wilmington
- 专利权人： E.I. duPont de Nemours and Company
- 当前专利权人： E.I. duPont de Nemours and Company
- 当前专利权人地址： US DE Wilmington
- 主分类号： C12N15/74
- IPC分类号： C12N15/74 ; C12N1/20 ; C12N15/63
摘要：
A method for the facile and inexpensive inducible expression of heterologous genes has been discovered. The yhcS regulator gene has been found to be inducible by aromatic carboxylic acids and to alter the expression of operons in the LysR gene family, including the yhcRQP operon, common in enteric bacteria. Heterologous nucleic acid molecules placed under the control of yhcS responsive promoters may be overexpressed in response to the presence of inexpensive aromatic carboxylic acids.
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